Preparation and evaluation of novel oral albumin formulation
| Project/Area Number |
22790044
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
IWAO Yasunori 静岡県立大学, 薬学部, 助教 (30433022)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 製剤学 |
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| Research Abstract |
In this study, we aimed to develop a novel oral album in formulation with high permeability to the intestinal membrane by using a combination of site-directed mutagenesis and emulsion method. It was found that domain III mutants showed high permeability from the MDCK cells compared with other mutants. In addition, as for the nanoparticles prepared by using the multiple mutated albumins, the nanoparticles showed a good permeability compared with control. These results indicate the feasibility of preparation of recombinant albumin nanoparticles with high permeability to the intestinal membrane.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] An easy-to-use approach for determining the disintegration ability of disintegrants by analysis of available surface area2013
Author(s)
Iwao, Y., Tanaka, S., Uchimoto, T., Noguchi, S., Itai., S.,
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Journal Title
International Journal of Pharmaceutics
Volume: 448
Pages: 1-8
Related Report
Peer Reviewed
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[Journal Article] Newly developed surface modification punches treated with alloying techniques reduce sticking during the manufacture of ibuprofen tablets2013
Author(s)
Uchimoto, T., Iwao, Y., Yamamoto, T., Sawaguchi, K., Moriuchi, T., Noguchi S., Itai, S.,
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Journal Title
International Journal of Pharmaceutics
Volume: 441
Pages: 128-134
Related Report
Peer Reviewed
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[Journal Article] A uremic toxin, 3-carboxy-4-methyl-5-propyl-2-furanpropionate induces cell damage to proximal tubular cells via the generation of a radical intermediate.2012
Author(s)
Miyamoto Y, Iwao Y, Mera K, Watanabe H, Kadowaki D, Ishima Y, Giam Chuang VT, Sato K, Otagiri M, Maruyama T.
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Journal Title
Biochemical Pharmacology
Volume: 84
Pages: 1207-1214
Related Report
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