Systemic delivery system of siRNAfor cancertreatment
| Project/Area Number |
22790045
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
ASAI Tomohiro 静岡県立大学, 大学院・薬学研究科, 准教授 (00381731)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ドラッグデリバリーシステム / small interfering RNA / がん治療 / ＲＮＡ干渉 / ｓｉＲＮＡ / がん / ＤＤＳ / リポソーム / RNA干渉 / siRNA / DDS |
|---|
| Research Abstract |
RNA interference effectorssuch assmall interfering RNA (siRNA) are promising therapeutic tools for treating cancer.Apractical and applicable delivery system is required to deliver enough of the therapeutic RNA to target tissues.In this study, we developed novel lipid nanoparticles carrying cholesterol-grafted siRNA for RNAi-based cancer therapy. Inhibitionof mammalian target of rapamycin(mTOR) signaling with siRNA systemically deliveredby thelipid nanoparticles resulted in tumor suppressionin vivo.
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Report
(4 results)
Research Products
(60 results)
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[Journal Article] Design and synthesis of high-avidity tetravalent glycoclusters as probes for Sambucus sieboldiana agglutinin and characterization of their binding properties2012
Author(s)
Ogata, M., Yano, M., Umemura, S., Murata, T., Park, E.Y., Kobayashi, Y., Asai, T., Oku, N., Nakamura, N., Matsuo, I., Usui, T.
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Journal Title
Bioconjugate Chem.
Volume: 23
Issue: 1
Pages: 97-105
DOI
Related Report
Peer Reviewed
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[Journal Article] Dicetyl phosphate-tetraethylenepentamine-based liposomes for systemic siRNA delivery.2011
Author(s)
T. Asai, S. Matsushita, E. Kenjo, T. Tsuzuku, N. Yonenaga, H. Koide, K. Hatanaka, T. Dewa, M. Nango, N. Maeda, H. Kikuchi, N. Oku
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Journal Title
Bioconjug. Chem.
Volume: 22
Issue: 3
Pages: 429-435
DOI
Related Report
Peer Reviewed
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