Strategy for therapy of atherosclerotic plaque by drug delivery system using immune-liposomes
Project/Area Number |
22790046
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Physical pharmacy
|
Research Institution | Hokkaido Pharmaceutical University School of Pharmacy |
Principal Investigator |
CHONO Sumio 北海道薬科大学, 薬学部, 教授 (90347790)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | ドラッグデリバリーシステム(DDS) / イムノリポソーム / 動脈プラーク / マクロファージ及び泡沫細胞 / DDS / 抗LOX1抗体 / マクロファージ / 泡沫細胞 / リポソーム |
Research Abstract |
Liposomes modified with anti-LOX1antibody(LOX1-liposomes) which recognizes macrophages and foam cells in atherosclerotic plaque were prepared and their efficacy for atherosclerotic therapy was examined. Targeting efficiency of LOX1-liposomes to atherosclerotic plaque of mice was greater than that of non-modified liposomes. Also, LOX1-liposomes containing anti-atherosclerotic drug significantly reduced atherosclerotic plaque of mice. This study suggests that LOX1-liposomes may be a new strategy for therapy of atherosclerotic plaque.
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Report
(3 results)
Research Products
(9 results)