Strategy for therapy of atherosclerotic plaque by drug delivery system using immune-liposomes

• Project/Area Number: 22790046
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Physical pharmacy
• Research Institution: Hokkaido Pharmaceutical University School of Pharmacy
• Principal Investigator: CHONO Sumio 北海道薬科大学, 薬学部, 教授 (90347790)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: ドラッグデリバリーシステム(DDS) / イムノリポソーム / 動脈プラーク / マクロファージ及び泡沫細胞 / DDS / 抗LOX1抗体 / マクロファージ / 泡沫細胞 / リポソーム

Research Abstract

Liposomes modified with anti-LOX1antibody(LOX1-liposomes) which recognizes macrophages and foam cells in atherosclerotic plaque were prepared and their efficacy for atherosclerotic therapy was examined. Targeting efficiency of LOX1-liposomes to atherosclerotic plaque of mice was greater than that of non-modified liposomes. Also, LOX1-liposomes containing anti-atherosclerotic drug significantly reduced atherosclerotic plaque of mice. This study suggests that LOX1-liposomes may be a new strategy for therapy of atherosclerotic plaque.

Research Products

• [Journal Article] DDS化のサイエンスと薬物治療 (2010)
  • Author(s): 丁野純男, 森本一洋
  • Journal Title: 道薬誌 Volume: 27 Pages: 5-10
• [Journal Article] 薬剤師が知っておきたいDDS製剤の機能とメカニズム
  • Author(s): 丁野純男
  • Journal Title: 薬局薬学 Volume: (印刷中)
• [Journal Article] ドラッグデリバリーシステムを利用した各種難治性疾患の新規治療戦略
  • Author(s): 丁野純男
  • Journal Title: 医薬品相互作用研究 Volume: (印刷中)
• [Journal Article] Uptake characteristics of anti-LOX1modified liposomes by macrophages and foam cells
  • Author(s): Chono S and Morimoto K
  • Journal Title: J. Drug Targ. Volume: (投稿中)
• [Journal Article] Efficient drug targeting to atherosclerotic lesions by anti-LOX1modified liposomes
  • Author(s): Chono S and Morimoto K
  • Journal Title: J. Control. Rel. Volume: (投稿中)
• [Presentation] クスリの宅急便ドラッグデリバリーシステム (2012)
  • Author(s): 丁野純男
  • Organizer: 第47回氷雪セミナー
  • Place of Presentation: 小樽
  • Year and Date: 2012-01-07
• [Presentation] リポソームの動脈硬化巣への集積性 (2011)
  • Author(s): 丁野純男, 森本一洋
  • Organizer: 第58回北海道薬学大会
  • Place of Presentation: 札幌
  • Year and Date: 2011-05-22
• [Remarks]
  • URL: http://www.hokuyakudai.ac.jp/outline/academic.html
• [Remarks]
  • URL: http://www.hokuyakudai.ac.jp/outline/academic.html