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DEVELOPMENT OF PERSONALIZED ANTICANCER THERAPY BY INHALABLE DRY POWDER BASED ON NONINVASIVE LUNG DEPOSITION MONITORING

Research Project

Project/Area Number 22790051
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Physical pharmacy
Research InstitutionMeijo University

Principal Investigator

OKUDA Tomoyuki  名城大学, 薬学部, 助教 (20513857)

Research Collaborator OKAMOTO Hirokazu  名城大学, 薬学部, 教授 (00308941)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords粉末吸入製剤 / 近赤外蛍光ラベル / in vivoイメージング / 肺癌治療 / 肺内送達 / テーラーメイド医療 / 噴霧急速凍結乾燥法 / 多孔性微粒子
Research Abstract

In this study, a novel inhalable dry anticancer powder containing doxorubicin(DOX) was prepared, labeled with a near-infrared fluorescent probe(indocyanin green ; ICG) for easily and noninvasively evaluating lung deposition. Following pulmonary administration of the powder into mice, it was suggested that the in-vivo fluorescence intensity in the lungs derived from ICG was significantly correlated not only with the ex-vivo fluorescence intensity in the excised lungs derived from DOX, but also with the anticancer effect in the lungs.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (6 results)

All 2012 2011 2010

All Presentation (6 results)

  • [Presentation] 噴霧急速凍結乾燥抗癌剤粉末微粒子の肺内投与後の体内動態および癌治療効果2012

    • Author(s)
      早野旭彦、右納寛、向山直樹、奥田知将、岡本浩一
    • Organizer
      第28回日本DDS学会学術集会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2012-07-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 肺癌治療への応用を目指した近赤外蛍光ラベル化吸入用抗癌剤粉末微粒子の開発2012

    • Author(s)
      早野旭彦、右納寛、向山直樹、奥田知将、岡本浩一
    • Organizer
      日本薬剤学会第27年会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2012-05-24
    • Related Report
      2011 Final Research Report
  • [Presentation] 肺癌治療への応用を目指した近赤外蛍光ラベル化吸入用抗癌剤粉末微粒子の開発2012

    • Author(s)
      早野旭彦、右納寛、向山直樹、奥田知将、岡本浩一
    • Organizer
      日本薬剤学会第27年会
    • Place of Presentation
      神戸国際会議場(予定)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 噴霧急速凍結乾燥抗癌剤粉末微粒子の肺内投与後の体内動態および癌治療効果2012

    • Author(s)
      早野旭彦、右納寛、向山直樹、奥田知将、岡本浩一
    • Organizer
      第28回日本DDS学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(予定)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 非侵襲性肺内送達量評価を可能とする抗癌剤粉末吸入製剤の開発2011

    • Author(s)
      早野旭彦、加藤沙紀、柳本真弥、奥田知将、岡本浩一
    • Organizer
      第57回日本薬学会東海支部総会・大会
    • Place of Presentation
      金城学院大学
    • Year and Date
      2011-07-09
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Non-invasive lung deposition monitoring of inhalable dry powder by near-infrared fluorescent labelling2010

    • Author(s)
      Tomoyuki Okuda
    • Organizer
      APSTJ Global Education Seminar West 10-2
    • Place of Presentation
      京都大学
    • Year and Date
      2010-12-21
    • Related Report
      2011 Final Research Report 2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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