Bile salt resistance of cell membrane acquired by ABCB4 and PEMT
| Project/Area Number |
22790053
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | Shiga University of Medical Science (2011)
Kobe Pharmaceutical University (2010) |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 生物物理化学 / ABCB4 / 細胞膜 / タウロコール酸 / 脂質ラフト / ホスファチジルコリン / スフィンゴミエリン / コレステロール / ホスファチジルエタノールアミン / ホスファチジルゴン / ホスファチジルエタノールアミンメチル基転移酵素 / 抱合型胆汁酸 / 非抱合型胆汁酸 / デュラマイシン / 微絨毛 |
|---|
| Research Abstract |
Phosphatidylethanolamine(PE) is converted to phosphatidylcholine(PC) in the liver by PE N-methyltransferase(PEMT). The expression of PEMT resulted in increased resistance to conjugated bile salts. PEMT may be important in the protection of hepatocytes from bile salts.
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Report
(3 results)
Research Products
(45 results)
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[Journal Article] Essential role of neuron-enriched diacylglycerol kinase(DGK), DGKb in neurite spine formation, contributing to cognitive function2010
Author(s)
Yasuhito Shirai, Takeshi Kouzuki, Kenichi Kakefuda, Shigeki Moriguchi, Atsushi Oyagi, Kyoji Horie, Shin-ya Morita, Masamitsu Shimazawa, Kohji Fukunaga, Junji Takeda, Naoaki Saito, Hideaki Hara
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Journal Title
PLoS ONE
Volume: 5
Pages: 7-7
Related Report
Peer Reviewed
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[Journal Article] Essential role of neuron-enriched diacylglycerol kinase (DGK), DGKb in neurite spine formation, contributing to cognitive function2010
Author(s)
Yasuhito Shirai, Takeshi Kouzuki, Kenichi Kakefuda, Shigeki Moriguchi, Atsushi Oyagi, Kyoji Horie, Shin-ya Morita, Masamitsu Shimazawa, Kohji Fukunaga, Junji Takeda, Naoaki Saito, Hideaki Hara
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Journal Title
PLoS ONE
Volume: 5
Pages: 7-7
Related Report
Peer Reviewed
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