| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
We here showed that type I and II IFN directly activated HSC and induced cell cycle entry and quiescence in HSC during virus infection. The IFN-mediated HSC activation was dependent on not only DC and NK cells, but also other IFN-producing cells. Moreover, IFN is important for inhibition of HSC mobilization and induction of HSC-autonomous immunity by IFN-induced proteins against intracellular virus.
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