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Regulation of Myelination and Glucose Metabolism by Phosphoinositides of Myelination of Myelination and Glucose Metabolism by Phosphoinositides

Research Project

Project/Area Number 22790055
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionAkita University

Principal Investigator

TAKASUGA Shunsuke  秋田大学, 大学院・医学系研究科, 助教 (90375262)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords脂質 / 脳神経疾患 / 糖尿病
Research Abstract

We made tissue-specific phosphatidylinositol 3-phosphate 5-kinase (PIPKIII) knockout mice for analyses of myelination in central nervous system and glucose metabolism in muscle. We indicated that essential roles of PIPKIII in oligodendrocytes. And we also found that PIPKIII is a negative regulator of insulin signaling in skeletal muscle.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (8 results)

All 2012 2011 2010

All Journal Article (6 results) (of which Peer Reviewed: 4 results) Presentation (2 results)

  • [Journal Article] 3'phosphatase activity toward PI (3,4) P2 by voltage-sensing phosphatase, VSP.2012

    • Author(s)
      Kurokawa T, Takasuga S, Sakata S, Yamaguchi S, Horie S, Homma KJ, Sasaki T, Okamura Y
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: (in press)

    • Related Report
      2011 Final Research Report
  • [Journal Article] Phosphoinositide 3-kinaseγ controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages2011

    • Author(s)
      Hazeki, K., Kametani, Y., et al, (11名中7番目)
    • Journal Title

      PLoS One.

      Volume: 6 Issue: 10 Pages: e26836-e26836

    • DOI

      10.1371/journal.pone.0026836

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The PI(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic Neuronal Death2010

    • Author(s)
      Sasaki, J., Kofuji, S., et al(20名中1番目, 2番目, 9番目, 10番目)
    • Journal Title

      Nature

      Volume: 465 Issue: 7297 Pages: 497-501

    • DOI

      10.1038/nature09023

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel acyl-coenzyme A : monoacylglycerol acyltransferase plays an important role in hepatic triacylglycerol secretion2010

    • Author(s)
      Hiramine Y, Emoto H, Takasuga S, Hiramatsu R
    • Journal Title

      J.Lipid Res

      Volume: 51 Issue: 6 Pages: 1424-1431

    • DOI

      10.1194/jlr.m002584

    • Related Report
      2011 Final Research Report
  • [Journal Article] The PtdIns(3,4)P_2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death.2010

    • Author(s)
      Sasaki J, Kofuji S, Itoh R, Momiyama T, Takayama K, Murakami H, Chida S, Tsuya Y, Takasuga S, Eguchi S, Asanuma K, Horie Y, Miura K, Davies EM, Mitchell C, Yamazaki M, Hirai H, Takenawa T, Suzuki A, Sasaki T.
    • Journal Title

      Nature

      Volume: 465 Pages: 497-501

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel acyl-coenzyme A : monoacylglycerol acyltransferase plays an important role in hepatic triacylglycerol secretion.2010

    • Author(s)
      Hiramine Y, Emoto H, Takasuga S, Hiramatsu R.
    • Journal Title

      J.Lipid Res.

      Volume: 51 Pages: 1424-1431

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Physiological function of phosphatidylinositol-3, 5-bisphosphate in vivo2010

    • Author(s)
      Takasuga S, Sasaki J, Suzuki A, Sasaki T
    • Organizer
      第62回日本細胞生物学会大会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-05-19
    • Related Report
      2011 Final Research Report
  • [Presentation] Physiological function of phosphatidylinositol-3,5-bisphosphate in vivo2010

    • Author(s)
      Takasuga S, Sasaki J, Suzuki A, Sasaki T.
    • Organizer
      第62回日本細胞生物学会大会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-05-19
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2023-03-16  

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