Regulation of Myelination and Glucose Metabolism by Phosphoinositides of Myelination of Myelination and Glucose Metabolism by Phosphoinositides

• Project/Area Number: 22790055
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: Akita University
• Principal Investigator: TAKASUGA Shunsuke 秋田大学, 大学院・医学系研究科, 助教 (90375262)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 脂質 / 脳神経疾患 / 糖尿病

Research Abstract

We made tissue-specific phosphatidylinositol 3-phosphate 5-kinase (PIPKIII) knockout mice for analyses of myelination in central nervous system and glucose metabolism in muscle. We indicated that essential roles of PIPKIII in oligodendrocytes. And we also found that PIPKIII is a negative regulator of insulin signaling in skeletal muscle.

Research Products

• [Journal Article] 3'phosphatase activity toward PI (3,4) P2 by voltage-sensing phosphatase, VSP. (2012)
  • Author(s): Kurokawa T, Takasuga S, Sakata S, Yamaguchi S, Horie S, Homma KJ, Sasaki T, Okamura Y
  • Journal Title: Proc Natl Acad Sci USA Volume: (in press)
• [Journal Article] Phosphoinositide 3-kinaseγ controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages (2011)
  • Author(s): Hazeki, K., Kametani, Y., et al, (11名中7番目)
  • Journal Title: PLoS One. Volume: 6 Issue: 10 Pages: e26836-e26836
  • DOI: 10.1371/journal.pone.0026836
  • Peer Reviewed
• [Journal Article] The PI(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic Neuronal Death (2010)
  • Author(s): Sasaki, J., Kofuji, S., et al(20名中1番目, 2番目, 9番目, 10番目)
  • Journal Title: Nature Volume: 465 Issue: 7297 Pages: 497-501
  • DOI: 10.1038/nature09023
  • Peer Reviewed
• [Journal Article] Novel acyl-coenzyme A : monoacylglycerol acyltransferase plays an important role in hepatic triacylglycerol secretion (2010)
  • Author(s): Hiramine Y, Emoto H, Takasuga S, Hiramatsu R
  • Journal Title: J.Lipid Res Volume: 51 Issue: 6 Pages: 1424-1431
  • DOI: 10.1194/jlr.m002584
• [Journal Article] The PtdIns(3,4)P_2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death. (2010)
  • Author(s): Sasaki J, Kofuji S, Itoh R, Momiyama T, Takayama K, Murakami H, Chida S, Tsuya Y, Takasuga S, Eguchi S, Asanuma K, Horie Y, Miura K, Davies EM, Mitchell C, Yamazaki M, Hirai H, Takenawa T, Suzuki A, Sasaki T.
  • Journal Title: Nature Volume: 465 Pages: 497-501
  • Peer Reviewed
• [Journal Article] Novel acyl-coenzyme A : monoacylglycerol acyltransferase plays an important role in hepatic triacylglycerol secretion. (2010)
  • Author(s): Hiramine Y, Emoto H, Takasuga S, Hiramatsu R.
  • Journal Title: J.Lipid Res. Volume: 51 Pages: 1424-1431
  • Peer Reviewed
• [Presentation] Physiological function of phosphatidylinositol-3, 5-bisphosphate in vivo (2010)
  • Author(s): Takasuga S, Sasaki J, Suzuki A, Sasaki T
  • Organizer: 第62回日本細胞生物学会大会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-05-19
• [Presentation] Physiological function of phosphatidylinositol-3,5-bisphosphate in vivo (2010)
  • Author(s): Takasuga S, Sasaki J, Suzuki A, Sasaki T.
  • Organizer: 第62回日本細胞生物学会大会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-05-19