| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
In this study, we investigated the metabolism of arachidonic acid in NPC. In addition, we examined the effect of sphingolipids accumulated in NPC on the metabolisms of arachidonic acid. We showed that 1) cPLA2α-dependent arachidonic acid metabolism plays important roles in the cytotoxicity and the ROS formation in NPC cells, 2) SM and LacCer are direct regulators of cPLA2α.
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