Role of arachidonic acid cascade on neurodegeneration in Niemann-Pick desease type C.
| Project/Area Number |
22790056
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | アラキドン酸代謝 / ニーマンピック病C型 / アラキドン酸カスケード / ホスホリパーゼA2 / コレステロール / 脂質代謝異常 |
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| Research Abstract |
In this study, we investigated the metabolism of arachidonic acid in NPC. In addition, we examined the effect of sphingolipids accumulated in NPC on the metabolisms of arachidonic acid. We showed that 1) cPLA2α-dependent arachidonic acid metabolism plays important roles in the cytotoxicity and the ROS formation in NPC cells, 2) SM and LacCer are direct regulators of cPLA2α.
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Report
(3 results)
Research Products
(50 results)
