Characterization of pathophysiological substrates of LRRK2, a causative gene product for familial Parkinson's disease
| Project/Area Number |
22790058
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ITO Genta 東京大学, 大学院・医学系研究科, 助教 (10431892)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | パーキンソン病 / LRRK2 / キナーゼ / GTP結合蛋白質 |
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| Research Abstract |
Several proteins have been reported to be phosphorylated by LRRK2 in vitro. However, they are not phosphorylated by LRRK2 in cells. In this study, we searched the database using the consensus phosphorylation sequence of LRRK2 as a query and selected a number of proteins as candidates. We examined whether they are phosphorylated by LRRK2 and found that several proteins including Synaptotagmin-1 were phosphorylated by LRRK2 in vitro.
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Report
(3 results)
Research Products
(14 results)
