Characterization of biosynthetic and self-protection mechanisms on novel bacteriocin produced by plant-derived LAB strain 174A

• Project/Area Number: 22790069
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: Hiroshima University
• Principal Investigator: NODA Masafumi 広島大学, 大学院・医歯薬保健学研究院, 特任講師 (40457289)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 微生物 / 発現制御 / バイオテクノロジー

Research Abstract

Brevicin 174A is classified into the class IIb bacteriocin, and is composed of two peptides, named brevicin 174A-βand 174A-γ. In the present study, the presumed target protein for brevicin 174A was found in the membrane fraction from brevicin 174A-sensitive lactic acid bacteria.

Research Products

• [Journal Article] 植物乳酸菌のヘルスサイエンス (2011)
  • Author(s): 杉山政則, 野田正文
  • Journal Title: New Food Industry Volume: 53 Pages: 7-14
  • NAID: 40019003953
• [Presentation] 齲蝕原性細菌のバイオフィルム形成を阻害する植物乳酸菌の探索研究 (2012)
  • Author(s): 町田千帆, 杉本好美, 野田正文, 島田歩, 小田康祐, 的場康幸, 熊谷孝則, 東川史子, 杉山政則
  • Organizer: 日本乳酸菌学会2012年度大会
  • Place of Presentation: 茨城県つくば市
• [Presentation] Correlation between lactic acid bacteria isolated from oral cavity of pre-school children and dental caries (2012)
  • Author(s): Masafumi Noda, Masanori Sugiyama
  • Organizer: The 5th International Symposium for lactic acid bacteria to urge industry-university cooperation
  • Place of Presentation: Seoul, Korea
• [Presentation] 齲蝕原性細菌のバイオフィルム形成を阻害する植物乳酸菌の探索研究 (2012)
  • Author(s): 町田 千帆
  • Organizer: 日本乳酸菌学会2012年度大会
  • Place of Presentation: つくば市
• [Presentation] Anti-obesity effect of plant-derived lactic acid bacteria isolated (2011)
  • Author(s): Masafumi Noda
  • Organizer: InnovAsia 2011: Food in the Future
  • Place of Presentation: Bangkok, Thailand
• [Presentation] Anti-obesity effect of plant-derived lactic acid bacteria isolated (2011)
  • Author(s): Masafumi Noda
  • Organizer: InnovAsia 2011 : Food in the Future
  • Place of Presentation: Thailand, Bangkok(Invited Lecture)
• [Presentation] 植物乳酸菌の予防医学への応用 (2010)
  • Author(s): 野田正文
  • Organizer: 長崎県工業技術センター平成22年度バイオ技術研究会
  • Place of Presentation: 長崎県大村市
  • Year and Date: 2010-07-22
• [Presentation] 植物乳酸菌の予防医学への応用 (2010)
  • Author(s): 野田正文
  • Organizer: 長崎県工業技術センター平成22年度バイオ技術研究会
  • Place of Presentation: 長崎県大村市(招待講演)
  • Year and Date: 2010-07-22
• [Presentation] 伊予柑より分離された乳酸菌174A株の産生する二種類のバクテリオシンの特性 (2010)
  • Author(s): 野田正文
  • Organizer: 日本乳酸菌学会2010年度大会
  • Place of Presentation: 宮城県仙台市
• [Presentation] Health benefit effects by plant-derived lactic acid bacteria (2010)
  • Author(s): Masafumi Noda
  • Organizer: 2010 International Symposium on "Green and Personalized Foods"
  • Place of Presentation: Daegu, Korea
• [Presentation] Health benefit effects by plant-derived lactic acid bacteria (2010)
  • Author(s): Masafumi Noda
  • Organizer: 2010 International Symposium on "Green and Personalized Foods"
  • Place of Presentation: Daegu, Korea(Invited Lecture)