| Project/Area Number |
22790070
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
|
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| Research Collaborator |
SHINOHARA Yasuo 徳島大学, 疾患ゲノム研究センター, 教授 (60226157)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 細胞生物学 / 透過性遷移 / ミトコンドリア / 酵母 / アポトーシス / 遺伝子破壊 / 遺伝子壊変 |
|---|
| Research Abstract |
Mitochondrial permeability transition triggers subsequent steps of apoptosis. To understand the molecular mechanisms of permeability transition, we in this research accessed to identify the regulatory genes for permeability transition using yeast mitochondria. As a result, we revealed that possible regulatory genes involved in permeability transition in previous reports did not mainly regulate permeability transition.
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