| Project/Area Number |
22790071
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Kochi University |
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Principal Investigator |
KOTANI Norihiro 高知大学, 教育研究部・医療学系, 助教 (90342782)
|
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| Research Collaborator |
HONKE Koichi 高知大学, 教育研究部・医療学系, 教授 (80190263)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 膜タンパク質 / 分子間相互作用 / Bリンパ腫細胞 / B細胞リンパ腫 |
|---|
| Research Abstract |
Many plasma membrane-resident proteins collaborate with other molecules by molecular interactions in a variety of biological events. Herein, we have studied interacted molecules associated with CD20-rituximab complex on B cell lymphoma cells. We found some cell surface molecules, such as FGFR3, HLA class II, and HSP-90 are interacted with CD20-rituximab complex. Above all, FGFR3 possibly plays important role for efficacy of rituximab-dependent cytotoxic effect through cell cycle signaling pathways.
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