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Characterization of signaling pathways that are regulated through cell surface molecular interaction in B cell lymphoma.

Research Project

Project/Area Number 22790071
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionKochi University

Principal Investigator

KOTANI Norihiro  高知大学, 教育研究部・医療学系, 助教 (90342782)

Research Collaborator HONKE Koichi  高知大学, 教育研究部・医療学系, 教授 (80190263)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords膜タンパク質 / 分子間相互作用 / Bリンパ腫細胞 / B細胞リンパ腫
Research Abstract

Many plasma membrane-resident proteins collaborate with other molecules by molecular interactions in a variety of biological events. Herein, we have studied interacted molecules associated with CD20-rituximab complex on B cell lymphoma cells. We found some cell surface molecules, such as FGFR3, HLA class II, and HSP-90 are interacted with CD20-rituximab complex. Above all, FGFR3 possibly plays important role for efficacy of rituximab-dependent cytotoxic effect through cell cycle signaling pathways.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (19 results)

All 2012 2011 2010

All Journal Article (7 results) (of which Peer Reviewed: 1 results) Presentation (12 results)

  • [Journal Article] A proteomics approach to the cell surface interactome using the enzyme-mediated activation of radical sources reaction2012

    • Author(s)
      Jiang S^#, Kotani N^<#*>, Ohnishi T, Miyagawa-Yamguchi A, Tsuda M, Yamashita R, Ishiura Y, Honke K
    • Journal Title

      Proteomics

      Volume: 12 Pages: 54-62

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Spatiotemporally-regulated interaction between beta1 integrin and ErbB4 that is involved in Fibronectin-dependent cell migration2011

    • Author(s)
      Yamashita R, Kotani N^*, Ishiura Y, Higashiyama S, Honke K
    • Journal Title

      J Biochem

      Volume: 149(3) Pages: 347-355

    • Related Report
      2011 Final Research Report
  • [Journal Article] The EMARS reaction : A new approach to identify partners of a given molecule in membrane microdomains(review)2011

    • Author(s)
      Honke K, Kotani N
    • Journal Title

      Neurochem

      Volume: 116(5) Pages: 690-695

    • Related Report
      2011 Final Research Report
  • [Journal Article] 新規ラジカル反応を用いた細胞膜上分子間相互作用の解析2011

    • Author(s)
      小谷典弘, 本家孝一
    • Journal Title

      生化学

      Volume: 83(8) Pages: 754-758

    • NAID

      10029575164

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] 生きている細胞の細胞表面で会合している分子を見つける2011

    • Author(s)
      本家孝一, 小谷典弘
    • Journal Title

      口腔組織培養学会誌

      Volume: 20(2) Pages: 1-8

    • Related Report
      2011 Final Research Report
  • [Journal Article] Anomalous expression of Thy1(CD90) in B-cell lymphoma cells and proliferation inhibition by anti-Thy1 antibody treatment2010

    • Author(s)
      Ishiura Y^#, Kotani N^<#*>, Yamashita R, Yamamoto H, Kozutsumi Y, Honke K
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 396(2) Pages: 329-334

    • Related Report
      2011 Final Research Report
  • [Journal Article] Anomalous Expression of Thy1 (CD90) in B-Cell Lymphoma Cells and Proliferation Inhibition by Anti-Thy1 Antibody Treatment2010

    • Author(s)
      Ishiura Y, Kotani N
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 396 Pages: 329-334

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 抗体医薬の効能や安全性を向上させる分子標的治療の標的分子探索2011

    • Author(s)
      小谷典弘, 石浦嘉人
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都国際会議場(京都府)
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Analysis of molecular clustering on the living cell membrane2011

    • Author(s)
      Honke K, Miyagawa-Yamguchi A and Kotani N
    • Organizer
      Glycobiology Japan-Netherland Joint Seminar 2011
    • Place of Presentation
      Nagoya University Graduate Scool of Medicine, Nagoya, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] A new EMARS system using HRP expressed by gene manipulation technology2011

    • Author(s)
      Yamaguchi A, Kotani N, Honke K
    • Organizer
      The 31^<th> NAITO CONFERENCE Hokkaido
    • Place of Presentation
      Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] EMARS反応-生きている細胞の表面で任意の分子と会合する分子を同定する-第61回日本電気泳動学会(JES)シンポジウム2011

    • Author(s)
      本家孝一、小谷典弘
    • Organizer
      第7回日本臨床プロテオーム研究会(JSCP) 2011連合大会
    • Place of Presentation
      山口
    • Related Report
      2011 Final Research Report
  • [Presentation] 抗体医薬の効能や安全性を向上させる分子標的治療の標的分子探索2011

    • Author(s)
      小谷典弘,石浦嘉人,大西知子,山下竜右,本家孝一
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] HRP遺伝子発現系を用いた新規EMARS法の開発2011

    • Author(s)
      山口亜利沙、小谷典弘、本家孝一
    • Organizer
      日本糖質学会
    • Place of Presentation
      新潟
    • Related Report
      2011 Final Research Report
  • [Presentation] Divergence of Cell Surface Molecular Interactions in Treatment of B-cell Lymphoma Cells with Different Anti-CD20 Antibody Clones2010

    • Author(s)
      Kotani N.
    • Organizer
      The 25^<th> International Carbohydrate Symposium
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2010-08-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Anomalous expression of Thy1(CD90) in B-cell Lymphoma cells and proliferation inhibition by anti-Thy1 antibody treatment2010

    • Author(s)
      Kotani N, Ishiura Y, Yamashita R, Yamamoto H, Kozutsumi Y, Honke K
    • Organizer
      GlycoT2010 Tokyo
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] A new approach to identify partners of a given molecule in membrane domains2010

    • Author(s)
      Honke K, Kotani N
    • Organizer
      4th ISN Special Neurochemistry Conference
    • Place of Presentation
      Sicily, Italy
    • Related Report
      2011 Final Research Report
  • [Presentation] Divergence of cell surface molecular interactions in treatment of B-cell lymphoma cells with different anti-CD20 antibody clones2010

    • Author(s)
      Kotani N, Ishiura Y, Yamashita R, Honke K
    • Organizer
      he 25^<th> International Carbohydrate Symposium
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Anomalous expression of Thy1(CD90) in B-cell lymphoma cells and proliferation inhibition by anti-Thy1 antibody treatment2010

    • Author(s)
      Kotani N, Ishiura Y, Yamashita R, Yamamoto H, Kozutsumi Y, Honke K
    • Organizer
      The 28^<th> NAITO CONFERENCE
    • Place of Presentation
      Kanagawa, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Fluorescence-labeled arylazide is suitable for proteomic approaches of EMARS-based cell surface interactome2010

    • Author(s)
      小谷典弘、山下竜右、石浦嘉人、本家孝一
    • Organizer
      BMB2010
    • Place of Presentation
      神戸
    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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