Effect of various molecular chaperones on the Alzheimer's disease.

• Project/Area Number: 22790073
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: Kumamoto University
• Principal Investigator: HOSHINO Tatuya 熊本大学, 大学院・生命科学研究部, 助教 (70457589)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 分子シャペロン / アルツハイマー / アミロイド

Research Abstract

Amyloid-peptide(Aβ) plays an important role in the pathogenesis of Alzheimer's disease(AD). HSP70 activity in relation to inhibition of Aβoligomerization and stimulation of Aβphagocytosis has also been reported. Transgenic mice expressing APPsw showed less of an apparent cognitive deficit when they were crossed with transgenic mice expressing HSP70. Transgenic mice expressing HSP70 also displayed lower levels of Aβ, Aβplaque deposition and neuronal and synaptic loss than control mice. These results suggest that overexpression of HSP70 in mice suppresses not only the pathological but also the functional phenotypes of AD.

Research Products

• [Journal Article] Improvement of cognitive function in Alzheimer's disease model mice by genetic and pharmacological inhibition of the EP_4 receptor (2012)
  • Author(s): Hoshino, T., et al
  • Journal Title: J.Neurochem. Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Acetaminophen-induced differentiation of human breast cancer stem cells and inhibition of tumor xenograft growth in mice (2011)
  • Author(s): Takehara, M., Hoshino, T., Namba, T., Yamakawa, N. and Mizushima, T
  • Journal Title: Biochem. Pharmacol Volume: 81 Pages: 1124-1135
  • Peer Reviewed
• [Journal Article] Suppression of Alzheimer's disease-related phenotypes by expression of heat shock protein 70 in mice (2011)
  • Author(s): Hoshino, T., Murao, N., Namba, T., Takehara, M., Adachi, H., Katsuno, M., Sobue, G., Matsushima, T., Suzuki, T. and Mizushima, T
  • Journal Title: J. Neurosci Volume: 31 Pages: 5225-5234
  • Peer Reviewed
• [Journal Article] Suppression of Alzheimer's disease-related phenotypes by expression of heat shock protein 70 in mice (2011)
  • Author(s): Hoshino, T., et al
  • Journal Title: J.Neurosci. Volume: 31 Pages: 5225-5234
  • Peer Reviewed
• [Journal Article] Acetaminophen-induced differentiation of human breast cancer stem cells and inhibition of tumor xenograft growth in mice (2011)
  • Author(s): Takehara, M., et al
  • Journal Title: Biochem.Pharmacol. Volume: 81 Pages: 1124-1135
  • Peer Reviewed
• [Journal Article] Suppression of expression of endoplasmic reticulum chaperones by Helicobacter pylori and its role in exacerbation of NSAID-induced gastric lesions (2010)
  • Author(s): Namba, T., Hoshino, T., Suemasu, S., Takarada-Iemata, M., Hori, O., Nakagata, N., Yanaka, A. and Mizushima, T
  • Journal Title: J. Biol. Chem Volume: 285 Pages: 37302-37313
  • Peer Reviewed
• [Journal Article] Suppression of melanin production by expression of HSP70 (2010)
  • Author(s): Hoshino, T., Matsuda, M., Yamashita, Y., Takehara, M., Fukuya, M., Mineda, K., Maji, D., Ihn, H., Adachi, H., Sobue, G., Funasaka, Y. and Mizushima, T
  • Journal Title: J. Biol. Chem Volume: 285 Pages: 13254-13263
  • Peer Reviewed
• [Journal Article] Prevention of ultraviolet B radiation-induced epidermal damage by expression of heat shock protein 70 (2010)
  • Author(s): Matsuda, M., Hoshino, T., Yamashita, Y., Tanaka, K., Maji, D., Sato, K., Adachi, H., Sobue, G., Ihn, H., Funasaka, Y. and Mizushima, T
  • Journal Title: J. Biol. Chem Volume: 285 Pages: 5848-5858
  • Peer Reviewed
• [Journal Article] Prevention of ultraviolet B radiation-induced epidermal damage by expression of heat shock protein 70. (2010)
  • Author(s): Matsuda.M., et al.
  • Journal Title: J.Biol.Chem. Volume: 285 Pages: 5848-5858
  • Peer Reviewed
• [Journal Article] Suppression of melanin production by expression of HSP70. (2010)
  • Author(s): Hoshino.T., et al.
  • Journal Title: J.Biol.Chem. Volume: 285 Pages: 13254-13263
  • Peer Reviewed
• [Journal Article] Suppression of expression of endoplasmic reticulum chaperones by Helicobacter pylori and its role in exacerbation of NSAID-induced gastric lesions. (2010)
  • Author(s): Namba.T., et al.
  • Journal Title: J.Biol.Chem. Volume: 285 Pages: 37302-37313
  • Peer Reviewed
• [Journal Article] Improvement of cognitive function in Alzheimer's disease model mice by genetic and pharmacological inhibition of the EP_4 receptor
  • Author(s): Hoshino, T., Namba, T., Takehara, M., Murao, N., Sugimoto, Y., Narumiya, S., Matsushima, T., Suzuki, T. and Mizushima, T
  • Journal Title: J. Neurochem Volume: (in press)
  • Peer Reviewed