Functional analyses of xylose-containing glycans in the nervous system
| Project/Area Number |
22790076
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
YAGI Hirokazu 名古屋市立大学, 大学院・薬学研究科, 助教 (70565423)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 糖鎖 / キシロース含有糖鎖 / キシロース転移酵素 / 神経系 |
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| Research Abstract |
This study aims to elucidate the function of xylosyl-containing glycans. We found that the candidate gene of xylosetransferase(AGO61)-knockout mice displayed embryonic growth retardation, especially brain development at embryonic day 11.5.The present study indicated that the xylosyl-containing glycans play important roles in the development of the nervous system.
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Report
(3 results)
Research Products
(26 results)
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[Journal Article] Bovine milk whey for preparation of natural N-glycans : structural and quantitative analysis2012
Author(s)
Sriwilaijaroen, N., Kondo, S., Yagi, H., Hiramatsu, H., Nakakita, S., Yamada, K., Ito, H., Hirabayashi, J., Narimatsu, H., Kato, K. and Suzuki, Y.
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Journal Title
Open Glycoscience
Volume: 5
Pages: 41-50
Related Report
Peer Reviewed
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[Journal Article] Comparative analysis of N-glycosylation profiles of influenza A viruses grown in different host cells2012
Author(s)
Yagi, H., Watanabe, S., Suzuki, T., Takahashi, T., Suzuki, Y. and Kato, K.
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Journal Title
Open Glycoscience
Volume: 5
Pages: 2-12
Related Report
Peer Reviewed
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[Journal Article] Bovine milk whey for preparation of natural N-glycans : structural and quantitative analysis2012
Author(s)
Sriwilaijaroen, N., Kondo, S., Yagi, H., Hiramatsu, H., Nakakita, S., Yamada, K., Ito, H., Hirabayashi, J., Narimatsu, H., Kato, K., Suzuki, Y.
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Journal Title
Open Glycoscience
Volume: 5
Issue: 1
Pages: 2-12
DOI
Related Report
Peer Reviewed
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[Journal Article] N-Glycans from porcine trachea and lung : Predominant NeuAcα2-6Gal could be a selective pressure for influenza variants in favor of human-type receptor2011
Author(s)
Sriwilaijaroen, N., Kondo, S., Yagi, H., Takemae, N., Saito, T., Hiramatsu, H., Kato, K. and Suzuki, Y.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] HNK-1 epitope-carrying Tenascin-C spliced variant regulates the proliferation of mouse embryonic neural stem cells2010
Author(s)
Yagi, H, Yanagisawa, M., Suzuki, Y., Nakatani, Y., Ariga, T., Kato, K., Yu, R. K.
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Journal Title
J. Biol. Chem
Volume: 285
Pages: 37293-37301
Related Report
Peer Reviewed
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