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Functional analyses of xylose-containing glycans in the nervous system

Research Project

Project/Area Number 22790076
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionNagoya City University

Principal Investigator

YAGI Hirokazu  名古屋市立大学, 大学院・薬学研究科, 助教 (70565423)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords糖鎖 / キシロース含有糖鎖 / キシロース転移酵素 / 神経系
Research Abstract

This study aims to elucidate the function of xylosyl-containing glycans. We found that the candidate gene of xylosetransferase(AGO61)-knockout mice displayed embryonic growth retardation, especially brain development at embryonic day 11.5.The present study indicated that the xylosyl-containing glycans play important roles in the development of the nervous system.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (26 results)

All 2012 2011 2010 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (13 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Bovine milk whey for preparation of natural N-glycans : structural and quantitative analysis2012

    • Author(s)
      Sriwilaijaroen, N., Kondo, S., Yagi, H., Hiramatsu, H., Nakakita, S., Yamada, K., Ito, H., Hirabayashi, J., Narimatsu, H., Kato, K. and Suzuki, Y.
    • Journal Title

      Open Glycoscience

      Volume: 5 Pages: 41-50

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative analysis of N-glycosylation profiles of influenza A viruses grown in different host cells2012

    • Author(s)
      Yagi, H., Watanabe, S., Suzuki, T., Takahashi, T., Suzuki, Y. and Kato, K.
    • Journal Title

      Open Glycoscience

      Volume: 5 Pages: 2-12

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bovine milk whey for preparation of natural N-glycans : structural and quantitative analysis2012

    • Author(s)
      Sriwilaijaroen, N., Kondo, S., Yagi, H., Hiramatsu, H., Nakakita, S., Yamada, K., Ito, H., Hirabayashi, J., Narimatsu, H., Kato, K., Suzuki, Y.
    • Journal Title

      Open Glycoscience

      Volume: 5 Issue: 1 Pages: 2-12

    • DOI

      10.2174/1875398101205010002

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development and application of multidimensional HPLC mapping method for O-linked oligosaccharides2011

    • Author(s)
      Yagi, H., Ohno, E., Kondo, S., Yoshida, A. and K. Kato
    • Journal Title

      Biomolecules

      Volume: 1 Pages: 48-62

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] N-Glycans from porcine trachea and lung : Predominant NeuAcα2-6Gal could be a selective pressure for influenza variants in favor of human-type receptor2011

    • Author(s)
      Sriwilaijaroen, N., Kondo, S., Yagi, H., Takemae, N., Saito, T., Hiramatsu, H., Kato, K. and Suzuki, Y.
    • Journal Title

      PLoS ONE

      Volume: 6

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structural and molecular basis of carbohydrate-protein interaction systems as potential therapeutic targets2011

    • Author(s)
      Kamiya, Y., Yagi-Utsumi, M., Yagi, H., Kato, K.
    • Journal Title

      Curr. Pharm. Des

      Volume: 17 Pages: 1672-1684

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] N-glycans from porcine trachea and lung : Predominant NeuAcα2-6Gal could be a selective pressure for influenza variants in favor of human-type receptor2011

    • Author(s)
      N. Sriwilaijaroen, S. Kondo, H. Yagi, N. T. T. Saito, H. Hiramatsu, K. Kato, Y. Suzuki
    • Journal Title

      PLoS ONE

      Volume: 6 Issue: 2 Pages: e16302-e16302

    • DOI

      10.1371/journal.pone.0016302

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural and molecular basis of carbohydrate?protein interaction systems as potential therapeutic targets.2011

    • Author(s)
      Y.Kamiya, M.Yagi-Utsumi, H.Yagi, and K.Kato
    • Journal Title

      Curr. Pharm. Des.

      Volume: 17 Issue: 17 Pages: 1672-1684

    • DOI

      10.2174/138161211796355074

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HNK-1 epitope-carrying Tenascin-C spliced variant regulates the proliferation of mouse embryonic neural stem cells2010

    • Author(s)
      Yagi, H, Yanagisawa, M., Suzuki, Y., Nakatani, Y., Ariga, T., Kato, K., Yu, R. K.
    • Journal Title

      J. Biol. Chem

      Volume: 285 Pages: 37293-37301

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] HNK-1 epitope-carrying Tenascin-C spliced variant regulates the proliferation of mouse embryonic neural stem cells2010

    • Author(s)
      Hirokazu Yagi, Makoto Yanagisawa, Yusuke Suzuki, Yoshihiko Nakatani, Toshio Ariga, Koichi Kato, Robert K.Yu
    • Journal Title

      Journal of Biological Chemistry

      Volume: 285 Pages: 37293-37301

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 神経幹細胞に発現しているLewisX型糖鎖はNotchシグナル経路を介して幹細胞性の維持に関与している2012

    • Author(s)
      矢木宏和, 齋藤拓也, 柳澤亮, Robert Yu, 加藤晃一
    • Organizer
      日本薬学会第132年会
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Identification of specific N-glycans expressed on the nervous systems by HPLC mapping method2012

    • Author(s)
      Hirokazu Yagi and Koichi Kato
    • Organizer
      GCOE International Symposium
    • Year and Date
      2012-01-11
    • Related Report
      2011 Final Research Report
  • [Presentation] Identification of specific N-glycans expressed on the nervous systems by HPLC mapping method2012

    • Author(s)
      Hirokazu Yagi, Koichi Kato
    • Organizer
      GCOE International Symposium
    • Place of Presentation
      名古屋
    • Year and Date
      2012-01-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] Lewis X containing glycans expressed on mouse embryonic neural stem cells regulates their proliferation via Notch signaling pathway2011

    • Author(s)
      Hirokazu Yagi, Takuya Saito, Makoto Yanagisawa, Robert K. Yu and Koichi Kato
    • Organizer
      第71回岡崎コンファレンス「糖鎖分子科学の新たな展望
    • Year and Date
      2011-10-13
    • Related Report
      2011 Final Research Report
  • [Presentation] Lewis X containing glycans expressed on mouse embryonic neural stem cells regulates their proliferation via Notch signaling pathway2011

    • Author(s)
      Hirokazu Yagi, Takuya Saito, Makoto Yanagisawa, Robert K.Yu, Koichi Kato
    • Organizer
      第71回岡崎コンファレンス「糖鎖分子科学の新たな展望
    • Place of Presentation
      岡崎
    • Year and Date
      2011-10-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] LewisX型糖鎖の神経細胞系における特異的な発現とその機能解析2011

    • Author(s)
      齋藤拓也, 矢木宏和, 柳澤亮, Robert K. Yu, 加藤晃一
    • Organizer
      第84回日本生化学会大会
    • Year and Date
      2011-09-22
    • Related Report
      2011 Final Research Report
  • [Presentation] The functional significance of the N-glycans in the differentiation of neural stem cells2011

    • Author(s)
      矢木宏和
    • Organizer
      第34回日本神経科学大会
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Development of multi-dimensional HPLC mapping for N-glycans and its application for functional glycomics2011

    • Author(s)
      Hirokazu Yagi, Noriko Takahashi, and Koichi Kato
    • Organizer
      98^<th> Session of the Indian Science Congress
    • Year and Date
      2011-01-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Development of multi-dimensional HPLC mapping for N-glycans and its application for functional glycomics2011

    • Author(s)
      Hirokazu Yagi, Noriko Takahashi, Koichi Kato
    • Organizer
      98^<th> Session of the Indian Science Congress
    • Place of Presentation
      SRM University(Chennai, India)
    • Year and Date
      2011-01-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] LewisX型糖鎖の神経細胞系における特異的な発現とその機能解析2011

    • Author(s)
      齋藤拓也, 矢木宏和, 柳澤亮, Robert K.Yu, 加藤晃一
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都(口頭)(ポスター)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 神経幹細胞における特異的糖鎖の発現と機能2010

    • Author(s)
      矢木宏和
    • Organizer
      2010年バイオインフォマティックス研究会
    • Year and Date
      2010-12-28
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] HNK-1 glyco-epitopes carried by the largest Tenascin-C spliced variant regulate proliferation of mouse embryonic neural stem cell2010

    • Author(s)
      Hirokazu Yagi, Makoto Yanagisawa, Koichi Kato, Robert K. Yu
    • Organizer
      第28回内藤カンファレンス
    • Year and Date
      2010-07-28
    • Related Report
      2011 Final Research Report
  • [Presentation] HNK-1 glyco-epitopes carried by the largest Tenascin-C spliced variant regulate proliferation of mouse embryonic neural stem cell2010

    • Author(s)
      Hirokazu Yagi, Makoto Yanagisawa, Koichi Kato, Robert K.Yu
    • Organizer
      第28回内藤カンファレンス
    • Place of Presentation
      湘南国際センター(神奈川)
    • Year and Date
      2010-07-28
    • Related Report
      2010 Annual Research Report
  • [Book] バイオ医薬品開発における糖鎖技術,(早川堯夫,掛樋一晃,平林淳監修)2011

    • Author(s)
      矢木宏和, 加藤晃一
    • Publisher
      シーエムシー出版
    • Related Report
      2011 Final Research Report
  • [Book] バイオ医薬品開発における糖鎖技術(早川堯夫,掛樋一晃,平林淳監修)2011

    • Author(s)
      矢木宏和, 加藤晃一
    • Total Pages
      10
    • Publisher
      シーエムシー出版
    • Related Report
      2011 Annual Research Report
  • [Remarks] ホームページ等名古屋市立大学大学院薬学研究科生命分子構造学分野

    • URL

      http://www.phar.nagoya-cu.ac.jp/hp/sbk/

    • Related Report
      2011 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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