| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
Staphylococcal superantigen-like (SSL) proteins, composed 14 member of exoprotein, share structural similarity with superantigens but no superantigenic activity. Several SSLs are known to be involved in immune evasion of S. aureus, however remaining SSLs are not identified their target proteins. In this study, we showed that SSL3 binds to TLR2, SSL8 binds to tenascin C, SSL10 binds to phosphatidyl serine and coagulation factors. We also showed the interactions between SSLs and the target proteins interferes the physiological functions of them.
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