Functional analysis of staphylococcal superantigen-like protein
Project/Area Number |
22790077
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Biological pharmacy
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Research Institution | Nagoya City University |
Principal Investigator |
ITOH Saotomo 名古屋市立大学, 大学院・薬学研究科, 講師 (70308013)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 免疫回避 / 細菌毒素 / 黄色ブドウ球菌 / 血液凝固 / アポトーシス / MMP-9 / IgG / フィコリン |
Research Abstract |
Staphylococcal superantigen-like (SSL) proteins, composed 14 member of exoprotein, share structural similarity with superantigens but no superantigenic activity. Several SSLs are known to be involved in immune evasion of S. aureus, however remaining SSLs are not identified their target proteins. In this study, we showed that SSL3 binds to TLR2, SSL8 binds to tenascin C, SSL10 binds to phosphatidyl serine and coagulation factors. We also showed the interactions between SSLs and the target proteins interferes the physiological functions of them.
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Report
(4 results)
Research Products
(56 results)
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[Presentation] Rheumatoid arthritis patient-derived synoviocytes are more sensitive to cigarette smoke condensate extracts-induced IL-1 beta expression through NF-κB activation than OA patient-derived synoviocytes, human lung fibroblasts and human lung epithelial cells2010
Author(s)
Onozaki kikuo, Okamoto Shosuke, Yokoyama Megumi, Arakawa Tomohiro, Adachi Miki,. Yamada Kyohei. Akita Kunihiko, Itoh Saotomo, Takii Takemasa, Waguri-Nagaya, Otsuka T Kazuichi
Organizer
18th International Symposium on Molecular CellBiology of Macrophages 2010
Place of Presentation
熊本
Year and Date
2010-05-20
Related Report
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[Book] Understanding Tuberculosis-New Approaches to Fighting Against Drug Resistance2012
Author(s)
Takemasa Takii, Yasuhiro Horita, Ryuji Kuroishi, Taku Chiba, Mashami Mori, Tomohiro Hasegawa, Tastuya Ito, Tatsuaki Tagami, Tetsuya Ozeki, Saotomo Ito, Kikuo Onozaki
Total Pages
10
Publisher
The Potential Therapeutic Usage of Dithiocarbamate Sugar Derivatives for Multi-Drug Resistant Tuberculosis
Related Report
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