The roles of fad104, a positive regulator of adipogenesis, in lung maturation

• Project/Area Number: 22790079
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: Nagoya City University
• Principal Investigator: NISHIZUKA Makoto 名古屋市立大学, 大学院・薬学研究科, 講師 (00363953)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: fad104 / 脂肪細胞分化 / 新生児疾患 / 肺形成 / 肺胞II型上皮細胞 / 肺胞上皮II型細胞 / 骨分化 / サーファクタントタンパク質

Research Abstract

In this study, we showed that novel gene fad104, a positive regulator of adipogenesis, has a crucial role for the differentiation of alveolar epithelial type II cells in lung maturation. Furthermore, we also demonstrated that fad104 was a potent inhibitor of osteblast differentiation.

Research Products

• [Journal Article] Indispensable role of factor for adipocyte differentiation 104(fad104) in lung maturation (2011)
  • Author(s): Kishimoto K, Nishizuka M, Ueda T, Kajita K., Ugawa S, Shimada S, Osada S, Imagawa M
  • Journal Title: Exp. Cell Res. Volume: 317(15) Pages: 2110-2123
  • Peer Reviewed
• [Journal Article] Factor for adipocyte differentiation 158 gene disruption prevents the body weight gain and insulin resistance induced by a high-fat diet (2011)
  • Author(s): Hayashi T, Nozaki Y, Nishizuka M, Ikawa M, Osada S, Imagawa M
  • Journal Title: Biol. Pharm. Bull. Volume: 34(8) Pages: 1257-1263
  • NAID: 130000936596
  • Peer Reviewed
• [Journal Article] Interleukin enhancer-binding factor 3 functions as a liver receptor homologue-1 co-activator in synergy with the nuclear receptor co-activators PRMT1 and PGC-1α (2011)
  • Author(s): Ohno M, Komakine J, Suzuki E, Nishizuka M, Osada S, Imagawa M
  • Journal Title: Biochem. J. Volume: 437(3) Pages: 531-540
  • Peer Reviewed
• [Journal Article] Indispensable role of factor for adipocyte differentiation 104 (fad104) in lung maturation (2011)
  • Author(s): Kishimoto K, Nishizuka M, Ueda T, Kajita K, Ugawa S, Shimada S, Osada S, Imagawa M
  • Journal Title: Exp.Cell Res. Volume: 317(15) Pages: 2110-2123
  • Peer Reviewed
• [Journal Article] Factor for adipocyte differentiation 158 gene disruption prevents the body weight gain and insulin resistance induced by a high-fat diet (2011)
  • Author(s): Hayashi T, Nozaki Y, Nishizuka M, Ikawa M, Osada S, Imagawa M
  • Journal Title: Biol.Pharm.Bull. Volume: 34(8) Pages: 1257-1263
  • NAID: 130000936596
  • Peer Reviewed
• [Journal Article] Interleukin enhancer-binding factor 3 functions as a liver receptor homologue-1 co-activator in synergy with the nuclear receptor co-activators PRMT1 and PGC-1α (2011)
  • Author(s): Ohno M, Komakine J, Suzuki E, Nishizuka M, Osada S, Imagawa M
  • Journal Title: Biochem.J. Volume: 437(3) Pages: 531-540
  • Peer Reviewed
• [Journal Article] Fad104, a positive regulator of adipogenesis, negatively regulates osteoblast differentiation (2010)
  • Author(s): Kishimoto K, Kato A, Osada S, Nishizuka M, Imagawa M
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 397(2) Pages: 187-191
  • Peer Reviewed
• [Journal Article] RNA interference-mediated knockdown of the mouse gene encoding potassium channel subfamily K member 10 inhibits hormone-induced differentiation of 3T3-L1 preadipocytes (2010)
  • Author(s): Sato S, Nishizuka M, Asano M, Ohtake T, Imagawa M, Kobayashi E
  • Journal Title: Comp. Biochem. Physiol. B Biochem. Mol. Biol. Volume: 157(1) Pages: 46-53
  • Peer Reviewed
• [Journal Article] Fad104, a positive regulator of adipogenesis, negatively regulates osteoblast differentiation. (2010)
  • Author(s): Kishimoto K, Kato A, Osada S, Nishizuka M, Imagawa M.
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 397(2) Pages: 187-191
  • Peer Reviewed
• [Journal Article] RNA interference-mediated knockdown of the mouse gene encoding potassium channel subfamily K member 10 inhibits hormone-induced differentiation of 3T3-L1 preadipocytes. (2010)
  • Author(s): Sato S, Nishizuka M, Asano M, Ohtake T, Imagawa M, Kobayashi E.
  • Journal Title: Comp.Biochem.Physiol.B Biochem.Mol.Biol. Volume: 157(1) Pages: 46-53
  • Peer Reviewed
• [Presentation] 脂肪細胞分化制御因子fad24がマウスの胚発生において担う機能の解析 (2012)
  • Author(s): 落合なつき、桐村拓也、長田茂宏、西塚誠、今川正良
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-30
• [Presentation] 新規遺伝子fad104が癌細胞の移動および浸潤能に与える影響の解析 (2012)
  • Author(s): 加藤大輝、西塚誠、岸本圭史、長田茂宏、今川正良
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-30
• [Presentation] 脂肪細胞分化制御因子fad24がマウスの胚発生において担う機能の解析 (2012)
  • Author(s): 落合なつき、桐村拓也、長田茂宏、西塚誠、今川正良
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌・北海道大学
  • Year and Date: 2012-03-30
• [Presentation] 新規遺伝子fad104が癌細胞の移動および浸潤能に与える影響の解析 (2012)
  • Author(s): 加藤大輝、西塚誠、岸本圭史、長田茂宏、今川正良
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌・北海道大学
  • Year and Date: 2012-03-30
• [Presentation] 脂肪細胞分化に重要なfad104の骨形成における役割 (2012)
  • Author(s): 岸本圭史、加藤愛友美、長田茂宏、西塚誠、今川正良
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-29
• [Presentation] 脂肪細胞分化に重要なfad104の骨形成における役割 (2012)
  • Author(s): 岸本圭史、加藤愛友美、長田茂宏、西塚誠、今川正良
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌・北海道大学
  • Year and Date: 2012-03-29
• [Presentation] Fad24, a novel gene promoting adipogenesis, is involved in early embryonic development and muscle regeneration (2011)
  • Author(s): 落合なつき、桐村拓也、長田茂宏、西塚誠、今川正良
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-13
• [Presentation] Fad24, a novel gene promoting adipogenesis, is involved in early embryonic development and muscle regeneration (2011)
  • Author(s): 落合なつき、桐村拓也、長田茂宏、西塚誠、今川正良
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜・パシフィコ横浜
  • Year and Date: 2011-12-13
• [Presentation] 新規遺伝子fad104がヒトメラノーマ細胞の移動能に与える影響の解析 (2011)
  • Author(s): 加藤大輝、西塚誠、岸本圭史、長田茂宏、今川正良
  • Organizer: 日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-11-23
• [Presentation] 新規遺伝子fad104がヒトメラノーマ細胞の移動能に与える影響の解析 (2011)
  • Author(s): 加藤大輝、西塚誠、岸本圭史、長田茂宏、今川正良
  • Organizer: 日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2011
  • Place of Presentation: 名古屋・ウインク愛知
  • Year and Date: 2011-11-23
• [Presentation] 脂肪細胞分化過程におけるKCNK10およびKCNK2の役割 (2011)
  • Author(s): 西塚誠、浅野真美、若林まい、佐藤周史、長田茂宏、今川正良
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-23
• [Presentation] 脂肪細胞分化過程におけるKCNK10およびKCNK2の役割 (2011)
  • Author(s): 西塚誠、浅野真美、若林まい、佐藤周史、長田茂宏、今川正良
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都・京都国際会館
  • Year and Date: 2011-09-23
• [Presentation] Fad104, a regulator of adipogenesis, is required for the differentiation of alveolar epithelial type II cell (2011)
  • Author(s): 岸本圭史、西塚誠、植田高史、梶田健二、鵜川眞也、島田昌一、長田茂宏、今川正良
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-22
• [Presentation] Fad104, a regulator of adipogenesis, is required for the differentiation of alveolar epithelial type II cell (2011)
  • Author(s): 岸本圭史、西塚誠、植田高史、梶田健二、鵜川眞也、島田昌一、長田茂宏、今川正良
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都・京都国際会館
  • Year and Date: 2011-09-22
• [Presentation] 脂肪細胞分化に関わる規遺伝子fad24の骨格筋における機能解析 (2011)
  • Author(s): 落合なつき、桐村拓也、岸本圭史、長田茂宏、西塚誠、今川正良
  • Organizer: 第57回日本薬学会東海支部総会・大会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-07-09
• [Presentation] 脂肪細胞分化に関わる規遺伝子fad24の骨格筋における機能解析 (2011)
  • Author(s): 落合なつき、桐村拓也、岸本圭史、長田茂宏、西塚誠、今川正良
  • Organizer: 第57回日本薬学会東海支部総会・大会
  • Place of Presentation: 名古屋・金城学院大学
  • Year and Date: 2011-07-09
• [Presentation] Novel gene fad104 is required for lung morphogenesis (2011)
  • Author(s): Kishimoto, Makoto Nishizuka, Shigehiro Osada, and Masayoshi Imagawa
  • Organizer: Experimental biology 2011(EB2011)
  • Place of Presentation: Washington D. C., U. S. A.
  • Year and Date: 2011-04-13
• [Presentation] Novel gene fad104 is required for lung morphogenesis (2011)
  • Author(s): Kishimoto K, Nishizuka M, Osada S, Imagawa M
  • Organizer: Experimental biology 2011 (EB2011)
  • Place of Presentation: Washington D.C., USA
  • Year and Date: 2011-04-13
• [Presentation] 脂肪細胞分化を正に制御する新規遺伝子fad24の生体内における機能の解析 (2011)
  • Author(s): 落合なつき、城村由和、岸本圭史、長田茂宏、西塚誠、今川正良
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-31
• [Presentation] 新規遺伝子fad104の細胞機能の解析 (2011)
  • Author(s): 加藤大輝、岸本圭史、加藤愛友美、長田茂宏、西塚誠、今川正良
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
• [Presentation] 脂肪細胞分化を正に制御する新規遺伝子fad24の生体内における機能解析 (2011)
  • Author(s): 落合なつき、城村由和、岸本圭史、長田茂宏、西塚誠、今川正良
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
• [Presentation] 新規遺伝子fad104は肺形成に必須である (2011)
  • Author(s): 岸本圭史、西塚誠、長田茂宏、今川正良
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
• [Presentation] 新規遺伝子fad24の生体内における機能解析 (2010)
  • Author(s): 落合なつき、城村由和、岸本圭史、長田茂宏、西塚誠、今川正良
  • Organizer: 第33回日本分子生物学会年会 第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-10
• [Presentation] The crucial role of fad104 in lung maturation (2010)
  • Author(s): Kishimoto K., Nishizuka M., Osada S., Imagawa M.
  • Organizer: 第33回日本分子生物学会年会 第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-09
• [Presentation] FAD104が骨分化に与える影響の解析 (2010)
  • Author(s): 加藤愛友美、岸本圭史、長田茂宏、西塚誠、今川正良
  • Organizer: 第74回日本生化学会中部支部例会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-05-29
• [Presentation] The crucial role of fad104 in lung maturation (2010)
  • Author(s): Keishi Kishimoto, Makoto Nishizuka, Shigehiro Osada, and Masayoshi Imagawa
  • Organizer: 第83回日本生化学会・第33回日本分子生物学会合同大会
  • Place of Presentation: 神戸
• [Presentation] 新規遺伝子fad24の生体内における機能解析 (2010)
  • Author(s): 落合なつき、城村由和、岸本圭史、長田茂宏、西塚誠、今川正良
  • Organizer: 第83回日本生化学会・第33回日本分子生物学会合同大会
  • Place of Presentation: 神戸
• [Presentation] 脂肪細胞分化を制御する新規遺伝子fad104の骨分化における役割 (2010)
  • Author(s): 加藤愛友美, 岸本圭史, 長田茂宏, 西塚誠, 今川正良
  • Organizer: 第9回次世代を担う若手ファーマ・バイオフォーラム2010
  • Place of Presentation: 京都