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The role of neutrophilic prostaglandin E synthase in stroke injury

Research Project

Project/Area Number 22790083
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionKitasato University

Principal Investigator

MATSUO Yuri  北里大学, 薬学部, 講師 (10306657)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords神経生物学 / 脳虚血 / プロスタグランジンE_2 / プロスタグランジンE合成酵素 / 好中球 / 炎症 / ノックアウトマウス / 神経細胞死 / 興奮毒性 / プロスタグランジンE2 / 血液脳関門
Research Abstract

Recently, we have found that microsomal PGE synthase(mPGES)-1 plays a crucial role in ischemic brain injury. mPGES-1 was expressed not only in neurons and microglia, but also in infiltrated neutrophils. Thus, we examined the role of neutrophlic mPGES-1 in exaggeration of brain ischemia. The number of infiltrated neutrophils observed in infarct regionof mPGES-1 KO mice was significantly less than that of WT mice. In thioglycollate-induced peritoneal neutrophils, the migrations induced by fMLP and IL-8 in mPGES-1 KO neutrophils were significantly lower than those in WT neutrophils. The neurotoxicity induced by glutamate was enhanced by co-culture with WT neutrophils, but not with mPGES-1 KO neutrophils. These results suggest that neutrophilic mPGES-1 contributes to ischemic brain injury by enhancing neutrophilic migration and neuronal excitotoxicity.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (14 results)

All 2012 2011 2010 Other

All Journal Article (6 results) (of which Peer Reviewed: 4 results) Presentation (7 results) Remarks (1 results)

  • [Journal Article] Inhibition of prostaglandin E_2EP3 receptors improves stroke injury via anti-inflammatory and anti-apoptotic mechanisms2011

    • Author(s)
      Ikeda-Matsuo Y, Tanji H, Narumiya S, Sasaki Y
    • Journal Title

      J. Neuroimmunol

      Volume: 238(1-2) Pages: 34-43

    • URL

      http://dx.doi.org/10.1016/j.jneuroim.2011.06.014

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of prostaglandin E_2 EP3 receptors improves stroke injury via anti-inflammatory and anti-apoptotic mechanisms2011

    • Author(s)
      Ikeda-Matsuo Y, Tanji H, Narumiya S, Sasaki Y
    • Journal Title

      J.Neuroimmunol.

      Volume: 238 Issue: 1-2 Pages: 34-43

    • DOI

      10.1016/j.jneuroim.2011.06.014

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microsomal prostaglandin E synthase-1 contributes to ischaemic excitotoxicity through prostaglandin EP_3receptors2010

    • Author(s)
      Ikeda-Matsuo Y, Tanji H, Ota A, Hirayama Y, Uematsu S, Akira S, Sasaki Y
    • Journal Title

      Br. J. Pharmacol

      Volume: 160 Issue: 4 Pages: 847-859

    • DOI

      10.1111/j.1476-5381.2010.00711.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are both required for ischaemic excitotoxicity2010

    • Author(s)
      Ikeda-Matsuo Y, Hirayama Y, Ota A, Uematsu S, Akira S, Sasaki Y
    • Journal Title

      Br. J. Pharmacol

      Volume: 159 Issue: 5 Pages: 1174-1186

    • DOI

      10.1111/j.1476-5381.2009.00595.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 病態生理からアプローチした薬物療法:炎症性疾患の病態生理2010

    • Author(s)
      佐々木泰治、松尾由理
    • Journal Title

      保険薬剤師さんのため実用情報誌

      Volume: No.10 Pages: 4-9

    • Related Report
      2011 Final Research Report
  • [Journal Article] Microsomal prostaglandin E synthase-1 is involved in the brain ischemic injury2010

    • Author(s)
      Ikeda-Matsuo Y
    • Journal Title

      Inflammation and Regeneration

      Volume: 30(1) Pages: 26-33

    • URL

      http://www.jsir.gr.jp/past_journal/3001/0026-0033.pdf

    • Related Report
      2011 Final Research Report
  • [Presentation] 脳虚血障害における好中球mPGES-1の役割2012

    • Author(s)
      松尾由理、平山友里、植松智、審良静男、田辺光男、佐々木泰治
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-14
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 虚血耐性獲得とアストロサイの活化-マウスMCAOMCAO MCAOモデルによる解析-モデルによる解析-モデルによる解析-2012

    • Author(s)
      平山友里、松尾由理、小泉修一
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-14
    • Related Report
      2011 Final Research Report
  • [Presentation] 脳炎症における膜結合型PGE合成酵素の役割2012

    • Author(s)
      松尾由理、内藤康仁、田辺敦弘、佐々木泰治、田辺光男
    • Organizer
      第29白金シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2012-01-18
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Microglial induction of microsomal prostaglandin E synthase-1 contributes to dopaminergic neuronal death in the mouse MPTP model of Parkinson's disease2010

    • Author(s)
      Ikeda-Matsuo Y, Kamoi M, Uematsu S, Akira S, Sasaki Y
    • Organizer
      The 29thNaito Conference ; Glia World
    • Place of Presentation
      Kanagawa
    • Year and Date
      2010-10-07
    • Related Report
      2011 Final Research Report
  • [Presentation] 膜結合型プロスタグランジンE合成酵素の誘導はマウス及びラット培養中脳神経細胞の6-ハイドロキシドパミンによるドパミン神経細胞死に寄与する2010

    • Author(s)
      松尾由理、溝口智子、植松智、審良静男、佐々木泰治
    • Organizer
      第53回日本神経化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Microsomal prostaglandin E synthase-1 and COX-2 are coordinatelycontribute to ischemic excitotoxicity through EP_3receptors2010

    • Author(s)
      Ikeda-Matsuo Y, Tanji H, Hirayama Y, Uematsu S, Akira S, Sasaki Y
    • Organizer
      World Pharma 2010(IUPHAR World Congress of Pharmacology)
    • Place of Presentation
      Copenhagen
    • Year and Date
      2010-07-19
    • Related Report
      2011 Final Research Report
  • [Presentation] Microsomal prostaglandin E synthase-1 and COX-2 are coordinately contribute to ischemic excitotoxicity through EP_3 receptors2010

    • Author(s)
      Yuri Ikeda-Matsuo, Hayato Tanji, Yuri Hirayama, Satoshi Uematsu, Shizuo Akira, Yasuharu Sasaki
    • Organizer
      WorldPharma 2010
    • Place of Presentation
      コペンハーゲン、デンマーク
    • Year and Date
      2010-07-19
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.pharm.kitasato-u.ac.jp/pharmacology/index.html

    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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