Development of a novel therapeutic strategy for Alzheimer's disease targeting on nicotinic acetylcholine receptors on microglia
| Project/Area Number |
22790090
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Research Collaborator |
谷口 隆之 京都薬科大学, 教授
下濱 俊 札幌医科大学, 教授
富本 秀和 三重大学, 教授
北村 佳久 京都薬科大学, 准教授
西村 周泰 CiRA, 研究員
ALFRED Maelicke Galantos, Pharma, CSO
佐伯 真菜 京都薬科大学, 大学院生
寺田 真希 京都薬科大学, 大学院生
鍵谷 沙智子 京都薬科大学, 大学院生
北村 理紗 京都薬科大学, 大学院生
辰田 博則 京都薬科大学, 大学院生
高田 哲也 京都薬科大学, 学部生
藤川 靖浩 京都薬科大学, 学部生
鶴野 友美 京都薬科大学, 学部生
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | アルツハイマー病 / アミロイドβ / ミクログリア / ニコチン性アセチルコリン受容体 / 貪食 / ガランタミン / アロステリック活性化リガンド / 骨髄細胞 / 骨髄幹細胞 / 移植 / macrophage-colony stimulating factor / 再生医療 / allosterically potentiating ligand / トランスジェニックマウス |
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| Research Abstract |
Galantamine is an acetylcholinesterase inhibitor approved for symptomatic treatment of Alzheimer's disease. Galantamine also acts as an allosterically potentiating ligand for nicotinic acetylcholine receptors(nAChRs). In this study, we demonstrated that galantamine stimulates nAChRs on microglia and promotes microglial phagocytic ability. This effect resulted in the reduction of amyloid-β burden in the brain which is thought to be a primary pathological event in the development of Alzheimer's disease. We further successfully differentiated bone-marrow cells to the microglia-like amyloid-β phagocytic cells.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Galantamine-induced amyloid-β clearance mediated via stimulation of microglial nicotinic acetylcholine receptors2010
Author(s)
Kazuyuki Takata, Yoshihisa Kitamura, Mana Saeki, Maki Terada, Sachiko Kagitani, Risa Kitamura, Yasuhiro Fujikawa, Alfred Maelicke, Hidekazu Tomimoto, Takashi Taniguchi, and Shun Shimohama
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Journal Title
J. Biol. Chem
Volume: 285
Pages: 40180-40191
Related Report
Peer Reviewed
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