Regulation of Wnt-3a signaling and diffusion by sulfated glycosaminoglycans

• Project/Area Number: 22790095
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: Kobe Pharmaceutical University
• Principal Investigator: NADANAKA Satomi 神戸薬科大学, 薬学部, 講師 (60378578)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 生化学 / 糖鎖生物学 / プロテオグリカン / コンドロイチン硫酸 / グリコサミノグリカン / Wntシグナル / 硫酸基転移酵素

Research Abstract

Wnt signaling is implicated in numerous physiological events such as morphogenesis. Here we found cis-acting element implicated in the transcriptional regulation of chondroitin 4-O-sulfotransferase(C4ST-1) gene by Wnt signaling

Research Products

• [Journal Article] Synthesis and interaction with midkine of biotinylated chondroitin sulfate tetrasaccharides (2012)
  • Author(s): Tamura, J., Tsutsumishita-Nakai, N., Nakao, Y., Kawano, M., Kato, S., Takeda, N., Nadanaka, S., and Kitagawa, H.
  • Journal Title: Bioorganic & Medicinal Chemistry Letters Volume: 22 Pages: 1371-1374
• [Journal Article] Down-regulation of chondroitin 4-O-sulfotransferase-1 by Wnt signaling triggers diffusion of Wnt-3a (2011)
  • Author(s): Nadanaka, S., Kinouchi, H., Taniguchi-Morita, K., Tamura, J., and Kitagawa, H.
  • Journal Title: J. Biol. Chem. Volume: 286 Pages: 4199-41208
• [Journal Article] Luminal domain of ATF6 alone is sufficient for sensing endoplasmic reticulum stress and subsequent transport to the Golgi apparatus (2011)
  • Author(s): Sato, Y., Nadanaka, S., Okada, T., and Mori, K.
  • Journal Title: Cell Struct. Funct. Volume: 36 Pages: 35-47
  • NAID: 40019163862
• [Journal Article] Regulation of Wnt-3a signaling and diffusion by sulfated glycosaminoglycans (2011)
  • Author(s): Nadanaka, S. and Kitagawa, H.
  • Journal Title: Seikagaku Volume: 83 Pages: 1027-1031
  • NAID: 10030345658
• [Journal Article] Down-regulation of chondroitin 4-O-sulfotransferase-1 by Wnt signaling triggers diffusion of Wnt-3a (2011)
  • Author(s): Nadanaka, S., Kinouchi, H., Taniguchi-Morita, K., Tamura, J., Kitagawa, H.
  • Journal Title: J.Biol.Cbem. Volume: 286 Issue: 6 Pages: 4199-41208
  • DOI: 10.1074/jbc.m110.155093
  • Peer Reviewed
• [Journal Article] Luminal Domain of ATF6 Alone Is Sufficient for Sensing Endoplasmic Reticulum Stress and Subsequent Transport to the Golgi Apparatus (2011)
  • Author(s): Sato, Y., Nadanaka, S., Okada, T., Mori, K.
  • Journal Title: Cell Structure and Function Volume: 36 Issue: 1 Pages: 35-47
  • DOI: 10.1247/csf.10010
  • NAID: 130004137562
  • ISSN: 0386-7196, 1347-3700
  • Peer Reviewed
• [Journal Article] 【Review】Regulation of Wnt-3a signaling and diffusion by sulfated glycosaminoglycans (2011)
  • Author(s): Nadanaka, S., Kitagawa, H.
  • Journal Title: Seikagaku Volume: 83 Pages: 1027-1031
  • Peer Reviewed
• [Journal Article] Down-regulation of chondroitin 4-O-sulfotransferase-1 by Wnt signaling triggers diffusion of Wnt-3a (2011)
  • Author(s): Nadanaka, S., Kinouchi, H., Kitagawa, H.
  • Journal Title: Journal Biological Chemistry Volume: 286 Pages: 4199-4208
  • Peer Reviewed
• [Journal Article] Luminal Domain of ATF6 Alone Is Sufficient for Sensing Endoplasmic Reticulum Stress and Subsequent Transport to the Golgi Apparatus. (2011)
  • Author(s): Sato, Y., Nadanaka, S., Okada, T., Mori, K.
  • Journal Title: Cell Structure Function Volume: 36 Pages: 35-47
  • NAID: 40019163862
  • Peer Reviewed
• [Journal Article] Biosynthesis of heparan sulfate in EXT1-deficient cells (2010)
  • Author(s): Okada, M., Nadanaka, S., Shoji N., Tamura, J., Kitagawa, H.
  • Journal Title: Biochemical Journal Volume: 428 Pages: 463-471
  • Peer Reviewed
• [Presentation] 硫酸化糖鎖による形態形成因子Wntのシグナル伝達と拡散の調節機構 (2011)
  • Author(s): 灘中里美、染谷健次、宮崎泰太、北川裕之
  • Organizer: 第30回日本糖質学会年会
  • Place of Presentation: 長岡
• [Presentation] Down-regulation of Chondroitin 4-O-sulfot ransferase-1 by Wnt Signaling Triggers Di ffusion of Wnt-3a (2011)
  • Author(s): Nadanaka, S., Kinouchi, H., Taniguchi-Morita, K., Tamura, J., and Kitagawa, H.
  • Organizer: 7th International Conference on Proteoglyc ans
  • Place of Presentation: Sydney, Australia
• [Presentation] Down-regulation of Chondroitin 4-O-sulfotransferase-1 by Wnt Signaling Triggers Diffusion of Wnt-3a (2011)
  • Author(s): Nadanaka. S., Kinouchi, H., Taniguchi-Morita, K., Tamura, J., Kitagawa, H.
  • Organizer: 7th International Conference on Proteoglycans
  • Place of Presentation: Sydney, Australia
• [Presentation] コンドロイチン4-O-硫酸基転移酵素によるWnt-3aシグナリングの微細調節 (2010)
  • Author(s): 灘中里美、木内啓貴、北川裕之
  • Organizer: 第42回結合組織学会
  • Place of Presentation: 秋田拠点センター・アルヴェ
• [Presentation] コンドロイチン4-O-硫酸基転移酵素-1によるWnt-3aの拡散制御 (2010)
  • Author(s): 木内啓貴、灘中里美、北川裕之
  • Organizer: 第33回分子生物学会第83回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド
• [Remarks]
• [Remarks] 神戸薬科大学生化学研究室ホームページ
  • URL: http://www.kobepharma-u.ac.jp/~biochem/