| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Non-alcoholic steatohepatitis(NASH) is recently recognized as a metabolic syndrome-related disease and proved to be an important risk factor for liver cirrhosis and cancer. Number of patient with NASH is rapidly increasing in economically advanced countries. Since molecular pathogenesis of NASH has not been cleared, precise diagnosis and effective therapy for NASH has not been established yet. To overcome such a situation, we searched disease-related proteins by using NASH model mice, CDAA-fed mice or TSOD mice. Proteome of liver tissues of NASH model mice and normal mice were compared by 2-dimentional differential gel electrophoresis(2D-DIGE). Proteins of differential expression were recovered from the gel and then identified by mass spectrometer. Further analysis of these proteins would lead to elucidation of molecular mechanism of development of NASH and development of promising diagnosis and therapeutic methods.
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