Development of Novel Fluorescent Probes for the Study of Receptor Localization and Environmental Change
Project/Area Number |
22790106
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Drug development chemistry
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
HIRANO Tomoya 東京医科歯科大学, 生体材料工学研究所, 准教授 (20396980)
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Project Period (FY) |
2010 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 医薬分子機能学 / ケミカルバイオロジー / 蛍光プローブ / 分子イメージング / 蛍光 / 合成化学 / クマリン / リガンド分子 / プロゲステロン受容体 |
Research Abstract |
Fluorescent sensors, whose fluorescent properties could be changed by each analyte, are especially useful in many field scientific research. In this project, we have developed some sensors for receptor proteins such as progesterone receptors or environmental change. By further optimization of these sensors, fluorescent imaging of cancer cells would be possible.
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Report
(3 results)
Research Products
(52 results)
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[Journal Article] Isolation and identification of C-19 fatty acids with anti-tumor activity from the spores of Ganoderma lucidum2012
Author(s)
Gao, P., Hirano, T., Chen, Z., Yasuhara, T., Nakata, Y., Sugimoto, A
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Journal Title
Fitoterapia
Volume: 83
Pages: 490-499
Related Report
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[Journal Article] Solventdependentconformational and fluorescen cechange of an N-phenylbenzohydroxamic acid derivative bearing two pyrene moieties2012
Author(s)
Kanai, M., Hirano, T.(Corresponding Author), Azumaya, I., Okamoto, I., Kagechika, H., Tanatani, A.
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Journal Title
Tetrahedron
Volume: 68
Pages: 2778-2783
Related Report
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[Journal Article] Boron Cluster-based Development of Potent Nonsecosteroidal Vitamin D Receptor Ligands : Direct Observation of Hydrophobic Interaction between Protein Surface and Carborane2011
Author(s)
Fujii, S., Masuno, H., Taoda, Y., Kano, A., Wongmayura, A., Nakabayashi, M., Ito, N., Shimizu, M., Kawachi, E., Hirano, T., Endo, Y., Tanatani, A., Kagechika, H.
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Journal Title
J. Am. Chem. Soc.
Volume: 133
Pages: 20933-20941
Related Report
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[Journal Article] 6-Arylcoumarins as Novel Non-steroidal Type Progesterone Antagonists : an Example with Receptor Binding-dependent Fluorescence2011
Author(s)
Sakai, H., Hirano, T.(Corresponding Author), Mori, S., Fujii, S., Masuno, H., Kinoshita, M., Kagechika, H., Tanatani, A.
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Journal Title
J. Med. Chem.
Volume: 54
Pages: 7055-7065
Related Report
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[Journal Article] Boron Cluster-based DevNon-Secosteroidal Vitamin D Receptor Ligands: Direct Observation of Hydrophobic Interaction between Protein Surface and Carborane2011
Author(s)
Shinya Fujii, Hiroyuki Masuno, Yoshiyuki Taoda, Atsushi Kano, Angsuma Wongmayura, Makoto Nakabayashi, Nobutoshi Ito, Masato Shimizu, Emiko Kawachi, Tomoya Hirano, YasuyukiEndo, Aya Tanatani, Hiroyuki Kagechika
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Journal Title
J. Am. Chem. Soc
Volume: 133
Issue: 51
Pages: 20933-20941
DOI
Related Report
Peer Reviewed
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[Journal Article] Development of Novel Bisubstrate-type Inhibitors of Histone Methyltransferase SET7/92010
Author(s)
Mori, S., Iwase, K, Iwanami, N., Tanaka, Y., Kagechika, H., Hirano, T.
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Journal Title
Bioorg. Med. Chem
Volume: 18
Pages: 8158-8166
Related Report
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[Journal Article] Latent Enamine Functionality of 5-Methyl-2, 3-dihydropyrazines2010
Author(s)
Ito, S., Hirano, T., Sugimoto, A., Kagechika H., Takechi, S., Yamaguchi, T.
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Journal Title
Chem. Pharm. Bull
Volume: 58
Pages: 922-977
NAID
Related Report
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