Novel modification method of oligonucleotides for siRNA medicine
| Project/Area Number |
22790107
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | Gifu University |
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Principal Investigator |
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| Research Collaborator |
KITADE Yukio 岐阜大学, 工学部, 教授 (20137061)
UENO Yoshihito 岐阜大学, 応用生物科学部, 教授 (20250467)
IKEDA Masato 岐阜大学, 工学部, 准教授 (20432867)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 核酸医薬 / siRNA / オリゴ核酸修飾 |
|---|
| Research Abstract |
Small interfering RNAs (siRNAs) are considered to be attractive candidates as nucleic acid drugs, owing to their powerful regulation of gene expression in a sequence-specific manner. In this study, novel some solid supports and synthetic method of artificial nucleic acids for chemically modified siRNA were developed.
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Report
(4 results)
Research Products
(11 results)
