| Project/Area Number |
22790124
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
SHIBATA Aya 独立行政法人理化学研究所, 伊藤ナノ医工学研究室, 基礎科学特別研究員 (50462693)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | グルタチオン-S-トランスフェラーゼ / アリールスルフォニル基 / 蛍光プローブ / 化学発光プローブ / ^<19> F-NMRプローブ / アリールスルホニル基 / 芳香族求核置換反応 |
|---|
| Research Abstract |
Our aim is to develop of the probe, which is protected by arylsulfonyl group, for GST detection. The deprotected molecule, which is not a glutathione conjugate, makes it possible to achieve signal cell retention. We succeeded in synthesis of fluorogenic probes, bioluminescent probes, 19F-NMR probes and prodrugs against GST activity.
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