| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
A target-specific phagocytes inducing agent for tumor cells was designed and synthesized. The 'eat-me' signal for phagocytes has been proposed to be phosphatidylserine (PS), which is exposed on the surface of dying cells. Gadolinium contrast medium makes certain tissues, abnormalities or disease processes more clearly visible on a magnetic resonance imaging (MRI) scans. The synthesized gadolinium conjugated PS analogues selectively recognized tumor cells. Tne PS accumulated on the surface of tumor cells induces macrophage by acting PS as the ‘ eat me signal’ and the tumor cell were efficiently phagocytosed by macrophages.
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