| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
Heavy metals such as cadmium and methylmercury are environmental pollutants that can target the vascular endothelium. In this study, we investigated the participation of transcription factor Nrf1 in cellular protective response to heavy metals. siRNA-mediated knockdown of Nrf1 resulted in an increase in sensitivity to cadmium and methylmercury in bovine aortic endothelial cells. Furthermore, exposure of cells to cadmium caused activation of Nrf1, leading to up-regulation of downstream genes such as NAD(P)H : quinone oxidereductase 1 and peroxiredoxin 1. Taken together, these results suggests that Nrf1 acts as a defense system against heavy metals. induced toxicity.
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