| Project/Area Number |
22790131
|
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental pharmacy
|
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| Research Institution | Kinjo Gakuin University (2011)
Gifu Pharmaceutical University (2010) |
|---|
Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
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| Keywords | トリフェニルスズ / 胸腺 / PPAR_γ / 脂肪化 / PPARγ / CD3陽性ナイーブT細胞 / 有機スズ化合物 |
|---|
| Research Abstract |
TPT administration in the wild-type mice decreased the thymus weight, increased adipose weight and enhanced the mRNA levels of PPAR_γ. aP2 and CD36 in the thymus. Furthermore, TPT promoted the thymic adipogenesis. On the other hand, the effect of TPT administration in PPAR. hetero-knockout mice tended to be lower than the wild-type mice. Flow cytometric analysis demonstrated a significant decrease in the thymus and spleen cell number and a slight decrease in the rate of naive T cell from the thymus. These results suggest that TPT promotes thymic atrophy, adipogenesis and aging via PPAR_γ.
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