Effect of overexposure to estrogen in fetal period on immediate allergic reaction

Research Project

Project/Area Number	22790132
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Environmental pharmacy
Research Institution	Gifu Pharmaceutical University
Principal Investigator	KOBAYASHI Ryo 岐阜薬科大学, 薬学部, 嘱託職員 (50555662)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	胎児期影響 / 免疫学 / 発生・分化 / 環境
Research Abstract	Exposure to some endocrine disruptors in fetal period can affect development of reproductive organs and the immune system. However, the effect of overexposure to estrogen in the fetal period remains unclear. In the current study, we generated a transgenic mice model that expressing aromatase driven by placenta-specific promoter(Arom TG mice) and investigated the effect of overexposure to estrogen in the fetal period on immediate allergic reaction. Ovalbumin-induced active cutaneous anaphylaxis in Arom TG mice was enhanced compared with that in wild-type mice. This finding suggests that overexposure to estrogen in the fetal period may affect antigen presentation.

Report

(3 results)