| Project/Area Number |
22790134
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2010-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | アデノシン / ATP / 味覚 / 味覚情報伝達 / エクトエンザイム / 味細胞 |
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| Research Abstract |
ATP is one of the intercellular signaling molecules in taste buds, and extracellular ATP fate is tightly regulated by its cellular clearance. However, there is a little information on ATPclearance-relating molecules and adenosine receptors in taste buds. Therefore, we examined expression profiles of ecto-nucleotidases, equilibrative nucleoside transporter (ENT) and ARs in rat circumvallate papillae (CP) by immunohistochemistry. ecto-nucleotide pyrophosphatase/phosphodiesterases (ENPP) 3 as a one of the ATP-degradating enzymes, prostatic acid phosphatase (PAP) as a one of the AMP-degradating enzymes, ENT1 as a one of the adenosine transporters, adenosine 2bR (A2bR) were detected in the rat CP. These results indicate that an ATP clearance system mediated by ecto-nucleotidases and ENTs and an adenosine signaling system mediated by A2bR, their coordination being considered to be important for gustatory signaling.
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