The effect of the food contaminants 3-MCPD and glycidol on immune responses

• Project/Area Number: 22790135
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Environmental pharmacy
• Research Institution: Kobe Pharmaceutical University
• Principal Investigator: YAMAKI Kouya 神戸薬科大学, 薬学部, 講師 (00351768)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 食品汚染物質 / 3-MCPD / グリシドール / 免疫 / T細胞

Research Abstract

We determined the effect of the food contaminants 3-MCPD and glycidol on immune responses. Our results indicated 3-MCPD and its derivative glycidol at or above concentration of 0.3% may potentially affect immune responses. Although the food contaminants at low concentrations in foods in usual might not affect human health, accidental contamination of the compounds at high concentration might affect immune responses upon its intake.

Research Products

• [Journal Article] Tyrosine kinase inhibitor sunitinib relieves systemic and oral antigen-induced anaphylaxes in mice (2012)
  • Author(s): Yamaki K, Yoshino S
  • Journal Title: Allergy Volume: 67 Pages: 114-22
• [Journal Article] Aspergillus oryzae lectin induces anaphylactoid oedema and mast cell activation through its interaction with fucose of mast cell-bound non-specific IgE (2011)
  • Author(s): Yamaki K, Yoshino S
  • Journal Title: Scand J Immunol Volume: 74 Pages: 445-53
• [Journal Article] Suppression of antibody-mediated arthritis in mice by Fab fragments of the mediating antibodies (2010)
  • Author(s): Yoshino S, Sasahara M, Hutamekalin P, Yamaki K, Mizutani N, Kuramoto H
  • Journal Title: Br J Pharmacol Volume: 161 Pages: 1351-60
• [Journal Article] Enhancement of FcεRI-mediated degranulation response in the rat basophilic leukemia cell line RBL2H3 by the fluorosurfactants perfluorooctanoic acid and perfluorooctane sulfonate (2010)
  • Author(s): Yamaki K, Yoshino S
  • Journal Title: Environ Toxicol Pharmacol Volume: 29 Pages: 183-9
• [Journal Article] Adjuvant effect of zinc oxide on Th2 but not Th1 immune responses in mice (2010)
  • Author(s): Matsumura M, Nagata M, Nakamura K, Kawai M, Baba T, Yamaki K, Yoshino S
  • Journal Title: Immunopharmacol Immunotoxicol Volume: 32 Pages: 56-62
• [Journal Article] Enhancement of FcεRI-mediated degranulation response in the rat basophilic leukemia cell line RBL2H3 by the fluorosurfactants perfluorooctanoic acid and perfluorooctane sulfonate. (2010)
  • Author(s): Yamaki K, Yoshino S.
  • Journal Title: Env.Toxicol.Pharmacol. Volume: 29 Pages: 183-189
  • Peer Reviewed
• [Journal Article] Suppression of antibody-mediated arthritis in mice by Fab fragments of the mediating antibodies. (2010)
  • Author(s): Yoshino S, Sasahara M, Hutamekalin P, Yamaki K, Mizutani N, Kuramoto H.
  • Journal Title: Br.J.Pharmacol. Volume: 161 Pages: 1351-1360
  • Peer Reviewed
• [Journal Article] Adjuvant effect of zinc oxide on Th2 but not Th1 immune responses in mice. (2010)
  • Author(s): Matsumura M, Nagata M, Nakamura K, Kawai M, Baba T, Yamaki K, Yoshino S.
  • Journal Title: Immunopharmacol.Immunotoxicol. Volume: 32 Pages: 56-62
  • Peer Reviewed
• [Presentation] マウス食物アレルギーモデルに対するチロシンキナーゼ阻害薬sunitinibの効果 (2012)
  • Author(s): 八巻耕也、吉野伸
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-30
• [Presentation] 環境汚染物質PFOAおよびPFOSによる肥満細胞のメディエーター放出促進 (2011)
  • Author(s): 八巻耕也、吉野伸
  • Organizer: 第115回日本薬理学会近畿部会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-07-08
• [Presentation] 肥満細胞のIgE依存的活性化に対する酸化亜鉛ナノ粒子およびマイクロ粒子の抑制作用の比較 (2011)
  • Author(s): 八巻耕也、吉野伸
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-30
• [Presentation] IgE依存的な肥満細胞の活性化に対する酸化亜鉛ナノ粒子と酸化亜鉛マイクロ粒子の抑制作用の比較 (2011)
  • Author(s): 八巻耕也、吉野伸
  • Organizer: 日本薬学会 第131年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-30