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Diagnostic method of Helicobacter heilmannii infection based on genetic analysis

Research Project

Project/Area Number 22790136
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Environmental pharmacy
Research InstitutionKobe Pharmaceutical University

Principal Investigator

MIKI Ikuya  神戸薬科大学, 薬学部, 講師 (30420467)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsヘリコバクターハイルマニ / ウレアーゼ
Research Abstract

Helicobacter heilmannii infection is possibly associated with gastric MALT lymphoma in mice model and human, and however, its diagnostic method has not been established yet. In this study, we succeed in the diagnosis of its infection with gastric mucosa by analyzing pathogenic genes of H. pylori and H. heilmannii. In the next step, we tried to establish the serodiagnosis using monoclonal antibody, but our antibody showed cross-reactivity. Therefore, we are going on analyzing the other virulent genes.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (3 results)

All 2012 2011

All Journal Article (3 results)

  • [Journal Article] Neonatal Fc receptor for IgG(FcRn) expressed in the gastric epithelium regulates bacterial infection in mice2012

    • Author(s)
      Ben Suleiman Y, Yoshida M, Nishiumi S, Tanaka H, Mimura T, Nobutani K, Yamamoto K, Takenaka M, Aoganghua A, Miki I, Ota H, Takahashi S, Matsui H, Nakamura M, Blumberg RS, Azuma T
    • Journal Title

      Mucosal Immunol

      Volume: 5 Pages: 87-98

    • Related Report
      2011 Final Research Report
  • [Journal Article] IFN-γ plays an essential role in the pathogenesis of gastric lymphoid follicles formation caused by Helicobacter suis infection2011

    • Author(s)
      Mimura T, Yoshida M, Nishiumi S, Tanaka H, Nobutani K, Takenaka M, Suleiman YB, Yamamoto K, Ota H, Takahashi S, Matsui H, Nakamura M, Miki I, Azuma T
    • Journal Title

      FEMS Immunol Med Microbiol

      Volume: 63 Pages: 25-34

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Helicobacter suis KB1 derived from pig gastric lymphoid follicles induces the formation of gastric lymphoid follicles in mice through the activation of B cells and CD4 positive cells2011

    • Author(s)
      Yamamoto K, Tanaka H, Nishitani Y, Nishiumi S, Miki I, Takenaka M, Nobutani K, Mimura T, Ben Suleiman Y, Mizuno S, Kawai M, Uchiyama I, Yoshida M, Azuma T
    • Journal Title

      Microbes Infect

      Volume: 13 Pages: 697-708

    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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