Development of a microRNA delivery system for cancer therapy
| Project/Area Number |
22790143
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Medical pharmacy
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | ドラッグデリバリー / 核酸医薬 / がん治療 / miRNA / siRNA / anti-miRNA oligo / 多機能性エンベロープ型ナノ構造体 / 癌治療 |
|---|
| Research Abstract |
Because miRNA/anti-miRNA oligonucleotide(AMO) are considered to be a potential therapeutic tool for cancer, the aim of the study is to development of AMO delivery system based on lipid nanoparticels(NPs). miRNA/AMO were successfully encapsulated in NPs. The systemic administration of NPs modified with functional device for improving intracellular trafficking could induce anti-tumor effect in in vivo tumor-bearing mice model
|
Report
(3 results)
Research Products
(45 results)
-
-
[Journal Article] Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid2011
Author(s)
Hatakeyama H, Akita H, Ito E, Hayashi Y, Oishi M, Nagasaki Y, Danev R, Nagayama K, Kaji N, Kikuchi H, Baba Y, Harashima H
-
Journal Title
Biomaterials
Volume: 32
Issue: 8
Pages: 4306-4316
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
