| Project/Area Number |
22790153
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Mie University |
|---|
Principal Investigator |
IWAMOTO Takuya 三重大学, 医学部・附属病院, 准教授 (30447867)
|
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| Research Collaborator |
OKUDA Masahiro 三重大学, 医学部附属病院, 教授 (70252426)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | シスプラチン / 腎障害 / 薬物トランスポータ / システイン複合体 |
|---|
| Research Abstract |
This study was performed to investigate the characteristics of renal tubular transport of N-acetylcysteine conjugate of cisplatin(CDDP-NAC, cytotoxic metabolite). In the human embryonic kidney 293(HEK293) cells transfected OCT2, OAT1 or OAT3, the CDDP-NAC accumulation in these cells was significantly lower than that of CDDP alone. NAC treatment prevented CDDP uptake in renal tubular cells, which might contribute to the reduced toxicity of CDDP.
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