To identify the genetic determinants of the inter-individual variability in human CYP3A activities
| Project/Area Number |
22790161
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
SARUWATARI Junji 熊本大学, 大学院・生命科学研究部, 助教 (30543409)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHITSU Takateru 国立病院機構熊本再春荘病院, 小児科, 医師
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | オーダーメード医療 / Cytochrome P450 3A / 遺伝子多型 / 核内受容体 / 薬物動態 / 酵素誘導 / 抗てんかん薬 / 母集団薬物動態解析 / cytochrome P450 3A |
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| Research Abstract |
We demonstrated that the genetic polymorphisms of nuclear receptors, pregnane X receptor and hepatocyte nuclear factor 4α, could affect the carbamazepine disposition and the CYP3A activity(i. e., the plasma 4β-hydroxycholesterol concentrations) in Japanese patients with epilepsy and healthy volunteers
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] A herbal-drug interaction study of keishi-bukuryo-gan, a traditional herbal preparation used for menopausal symptoms2012
Author(s)
Saruwatari J, Takaishi C, Yoshida K, Takashima A, Fujimura Y, Umemoto Y, Abe T, Kitamado M, Shimomasuda M, Muramoto Y, Nakagawa K
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Journal Title
J Pharm Pharmacol
Volume: 64
Pages: 670-676
Related Report
Peer Reviewed
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[Journal Article] Superoxide dismutase 2 Val16Ala polymorphism is a risk factor for the valproic acid-related elevation of serum aminotransferases2012
Author(s)
Saruwatari J, Deguchi M, Yoshimori Y, Noai M, Yoshida S, Ogusu N, Oniki K, Yoshida S, Yasui-Furukori N, Kaneko S, Ishitsu T, Nakagawa K
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Journal Title
Epilepsy Res
Volume: 99
Pages: 183-186
Related Report
Peer Reviewed
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[Journal Article] The clinical impact of cytochrome P450 polymorphisms on anti-epileptic drug therapy2010
Author(s)
Saruwatari J, Ishitsu T, Seo T, Shimomasuda M, Okada Y, Goto S, Nagata R, Takashima A, Yoshida S, Yoshida S, Yasui-Furukori N, Kaneko S, Nakagawa K
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Journal Title
Epilepsy & Seizure
Volume: 3
Pages: 34-50
NAID
Related Report
Peer Reviewed
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[Presentation] 個別化投与設計を目指した抗てんかん薬の薬理遺伝学的検討2011
Author(s)
猿渡淳二, 大楠直樹, 吉田志保, 下益田正嗣, 津田義之, 瀬尾享志, 後藤周志, 中田直之, 古郡規雄, 兼子直, 石津棟暎, 中川和子
Organizer
第32回日本\臨床薬理学会年会
Place of Presentation
アクトシティ浜松(静岡)
Year and Date
2011-12-01
Related Report
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[Presentation] カルバマゼピン単剤治療における核内受容体遺伝子多型の影響2011
Author(s)
吉田志保, 猿渡淳二, 岡田祐輔, 大楠直樹, 津田義之, 野相まどか, 今村元紀, 吉田昂佑, 高嶋綾佳, 鬼木健太郎, 古郡規雄, 兼子直, 石津棟暎, 中川和子
Organizer
第21回日本臨床精神神経薬理学会・第41回日本神経精神薬理学会
Place of Presentation
京王プラザホテル(東京)
Year and Date
2011-10-27
Related Report
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