| Project/Area Number |
22790161
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
SARUWATARI Junji 熊本大学, 大学院・生命科学研究部, 助教 (30543409)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHITSU Takateru 国立病院機構熊本再春荘病院, 小児科, 医師
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | オーダーメード医療 / Cytochrome P450 3A / 遺伝子多型 / 核内受容体 / 薬物動態 / 酵素誘導 / 抗てんかん薬 / 母集団薬物動態解析 / cytochrome P450 3A |
|---|
| Research Abstract |
We demonstrated that the genetic polymorphisms of nuclear receptors, pregnane X receptor and hepatocyte nuclear factor 4α, could affect the carbamazepine disposition and the CYP3A activity(i. e., the plasma 4β-hydroxycholesterol concentrations) in Japanese patients with epilepsy and healthy volunteers
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