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Development of Nitric oxide traffic protein as a novel drug againstischemic diseases

Research Project

Project/Area Number 22790162
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Medical pharmacy
Research InstitutionKumamoto University

Principal Investigator

ISHIMA Yu  熊本大学, 薬学部, 助教 (00457590)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords薬物動態学 / ドラッグデリバリーシステム / ヒト血清アルブミン / 一酸化窒素 / 虚血性疾患 / S-ニトロソ化 / 臓器移植 / NOトラフィックタンパク質 / 遺伝子組換え / 虚血再灌流障害 / S-ニトロン化
Research Abstract

S-Nitrosated human serum albumin (SNO-HSA) is useful in preventing liverischemia/reperfusion injury, and SNO-HSA should thus be able to prevent cell injury duringliver transplantation. However, the potential protective effect of SNO-HSA on acombination of cold and warm ischemia, which is obligatory when performing livertransplantation, has not been examined. Our results indicate that a combination of SNO-HSAand UW solution can be used to prevent the two types of ischemia. Therefore, SNO-HSA-addedUW solution could be very useful in transplantation, because the previously imposedconstraints on preservation time can be removed. This is a great advantage in a situationas the present one with increased utilization of scarce donor organs for more recipients

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (71 results)

All 2013 2012 2011 2010

All Journal Article (36 results) (of which Peer Reviewed: 36 results) Presentation (26 results) (of which Invited: 2 results) Patent(Industrial Property Rights) (9 results)

  • [Journal Article] UW solution improved with highanti-apoptotic activity byS-nitrosated human serum albumin2013

    • Author(s)
      IshimaY, Shinagawa T, Yoneshige S,Kragh-Hansen U, Ohya Y, Inomata Y,Kai T, Otagiri M, Maruyama T.
    • Journal Title

      Nitric Oxide

      Volume: 30 Pages: 36-42

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Albumin domain II mutant with highbilirubin binding affinity has agreat potential as serum bilirubinexcretion enhancer forhyperbilirubinemia treatment2013

    • Author(s)
      Minomo A, Ishima Y, ChuangVT, Suwa Y, Kragh-Hansen U, NarisokoT, Morioka H, Maruyama T, Otagiri M
    • Journal Title

      Biochim Biophys Acta

      Volume: 1830 Pages: 2917-23

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] p-Cresyl sulfate causes renaltubular cell damage by inducingoxidative stress by activation ofNADPH oxidase2013

    • Author(s)
      Watanabe H, Miyamoto Y,Honda D, Tanaka H, Wu Q, Endo M,Noguchi T, Kadowaki D, Ishima Y,Kotani S, Nakajima M, Kataoka K,Kim-Mitsuyama S, Tanaka M, FukagawaM, Otagiri M, Maruyama T.
    • Journal Title

      Kidney Int

      Volume: 83 Pages: 582-92

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A human serum albumin-thioredoxinfusion protein preventsexperimental contrast-inducednephropathy2013

    • Author(s)
      Kodama A, Watanabe H, TanakaR, Tanaka H, Chuang VT, Miyamoto Y,Wu Q, Endo M, Hamasaki K, Ishima Y,Fukagawa M, Otagiri M, Maruyama T.
    • Journal Title

      Kidney Int

      Volume: 83 Pages: 446-54

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] S-nitrosated α-1-acidglycoprotein kills drug-resistantbacteria and aids survival in sepsis2013

    • Author(s)
      WatanabeK, Ishima Y, Akaike T, Sawa T, KurodaT, Ogawa W, Watanabe H, Suenaga A,Kai T, Otagiri M, Maruyama T.
    • Journal Title

      FASEB J

      Volume: 27 Pages: 391-8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] UW solution improved with high anti-apoptotic activity by S-nitrosated human serum albumin.2013

    • Author(s)
      Ishima Y
    • Journal Title

      Nitric Oxide.

      Volume: 印刷中 Pages: 36-42

    • DOI

      10.1016/j.niox.2013.01.004

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Albumin domain II mutant with high bilirubin binding affinity has a great potential as serum bilirubin excretion enhancer for hyperbilirubinemia treatment.2013

    • Author(s)
      Minomo A
    • Journal Title

      Biochim Biophys Acta.

      Volume: 印刷中 Issue: 4 Pages: 141-8

    • DOI

      10.1016/j.bbagen.2013.01.006

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p-Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress byactivation of NADPH oxidase.2013

    • Author(s)
      Hiroshi Watanabe^*, Yohei Miyamoto^*,Daisuke Honda, Hisae Tariaka, Qiong Wu,Masayuki Endo, Tsuyoshi Noguchi, DaisukeKadowaki, Yu Ishima, Shunsuke Kotani,Makoto Nakajima, Keiichiro Kataoka,Shokei Kim-Mitsuyama, Motoko Tanaka,Masafumi Fukagawa, Masaki Otagiri, ToruMaruyama. (^*:Hiroshi Watanabe and YoheiMiyamoto contributed equally to this work.)
    • Journal Title

      Kidney International

      Volume: (印刷中) Issue: 4 Pages: 582-592

    • DOI

      10.1038/ki.2012.448

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A human serum albumin-thioredoxin fusion protein prevents experimental contrast-induced nephropathy.2013

    • Author(s)
      Kodama A
    • Journal Title

      Kidney Int.

      Volume: 印刷中 Issue: 3 Pages: 446-54

    • DOI

      10.1038/ki.2012.429

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] S-nitrosylated a-l-acid glycoprotein kills drug-resistant bacteria and aids survival in sepsis2013

    • Author(s)
      Watanabe K, Ishima Y, Akaike T, Sawa T, Kuroda T, Ogawa W, Watanabe H, Suenaga A, Kai T, Otagiri M, and Maruyama T.
    • Journal Title

      FASEB J

      Volume: 27 Issue: 1 Pages: 391-398

    • DOI

      10.1096/fj.12-217794

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction between two sulfate-conjugated uremic toxins, p-cresyl sulfate and indoxyl sulfate, during binding with human serum albumin.2013

    • Author(s)
      Watanabe H
    • Journal Title

      Biochim Biophys Acta.

      Volume: 40 Issue: 7 Pages: 1423-8

    • DOI

      10.1124/dmd.112.045617

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elucidation of the therapeuticenhancer mechanism ofpoly-S-nitrosated human serum albuminagainst multidrug-resistant tumor inanimal models2012

    • Author(s)
      Ishima Y, Hara M,Kragh-Hansen U, Inoue A, Suenaga A,Kai T, Watanabe H, Otagiri M, MaruyamaT.
    • Journal Title

      J Control Release

      Volume: 164 Pages: 1-7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A uremic toxin,3-carboxy-4-methyl-5-propyl-2-furanpropionate induces cell damage toproximal tubular cells via thegeneration of a radical intermediate2012

    • Author(s)
      Miyamoto Y, Ishima Y,Otagiri M, Maruyama T.
    • Journal Title

      Biochem Pharmacol

      Volume: 84 Pages: 1207-1214

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interaction between twosulfate-conjugated uremic toxins,p-cresyl sulfate and indoxyl sulfate,during binding with human serumalbumin2012

    • Author(s)
      Watanabe H, Miyamoto Y,Ishima Y, Otagiri M, Maruyama T.
    • Journal Title

      Drug Metab Dispos

      Volume: 40 Pages: 1423-1428

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] S-guanylation of human serum albuminis a unique posttranslationalmodification and results in a novelclass of antibacterial agents2012

    • Author(s)
      Ishima Y,Akaike T, Maruyama T, Otagiri M.
    • Journal Title

      J PharmSci

      Volume: 101 Pages: 3222-3229

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative evaluation of the role ofcysteine and methionine residues inthe antioxidant activity of humanserum albumin using recombinantmutants2012

    • Author(s)
      Ishima Y, Maruyama T, Otagiri M.
    • Journal Title

      IUBMB Life.

      Volume: 64 Pages: 450-454

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] S-Nitrosated human serum albumindimer is not only a novel anti-tumordrug but also a potentiator foranti-tumor drugs with augmented EPReffects2012

    • Author(s)
      Ishima Y, Maeda H, MaruyamaT, Otagiri M.
    • Journal Title

      Bioconjug Chem.

      Volume: 23 Pages: 264-271

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Elucidation of the therapeutic enhancer mechanism of poly-S-nitrosated human serum albumin against multidrug-resistant tumor in animal models.2012

    • Author(s)
      Ishima Y
    • Journal Title

      J Control Release.

      Volume: 164 Issue: 1 Pages: 1-7

    • DOI

      10.1016/j.jconrel.2012.10.003

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A uremic toxin, 3-carboxy-4-methyl-5-propyl-2-furanpropionate induces cell damage to proximal tubular cells via the generation of a radical intermediate.2012

    • Author(s)
      Yohei Miyamoto, Yasunori Katsumi Mera, Hiroshi Watanabe, Daisuke Kadowaki, Yu Ishima, Victor Tuan Giam Chuang, Keizo Sato, Masaki Otagiri, Toru Maruyama.
    • Journal Title

      Biochemical Pharmacology

      Volume: 84 Issue: 9 Pages: 1207-1214

    • DOI

      10.1016/j.bcp.2012.07.033

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] S-Guanylation of human serum albumin is a unique posttranslational modification and results in a novel class of antibacterial agents2012

    • Author(s)
      Ishima Y, Hoshino H, Shinagawa T, Watanabe K, Akaike T, Sawa T, Kragh-Hansen U, Kai T, Watanabe H, Maruyama T, and Otagiri M
    • Journal Title

      J. Pharm. Sci

      Volume: 101 Issue: 9 Pages: 3222-3229

    • DOI

      10.1002/jps.23143

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative evaluation of the role of cysteine and methionine residues in the antioxidant activity of human serum albumin using recombinant mutants2012

    • Author(s)
      Iwao Y
    • Journal Title

      IUBMB Life

      Volume: 64 Issue: 5 Pages: 450-454

    • DOI

      10.1002/iub.567

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] S-Nitrosated human serum albumin dimer is not only a novel anti-tumor drug but also a potentiator for anti-tumor drugs with augmented EPR effects2012

    • Author(s)
      Ishima Y
    • Journal Title

      Bioconjug Chem

      Volume: 23 Issue: 2 Pages: 264-271

    • DOI

      10.1021/bc2005363

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biological characteristics of two lysines on human serum albumin in the high-affinity binding of 4Z,15Z-bilirubin-IXα revealed by phage display2012

    • Author(s)
      Minomo A
    • Journal Title

      FEBS J

      Volume: 278 Pages: 4100-4111

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biological characteristics of twolysines on human serum albumin in thehigh-affinity binding of 4Z,15Z-bilirubin-IX α revealed byphage display2011

    • Author(s)
      Minomo A, Ishima Y,Kragh-Hansen U, Maruyama T, OtagiriM.
    • Journal Title

      FEBS J

      Volume: 278 Pages: 4100-4111

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cellular uptake mechanisms andresponses to NO transferred frommono- and poly-S-nitrosated humanserum albumin2011

    • Author(s)
      Ishima Y, Yoshida F,Akaike T, Maruyama T, Otagiri M.
    • Journal Title

      Free Radic Res

      Volume: 45 Pages: 1196-1206

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human serum albumin-thioredoxinfusion protein with long bloodretention property is effective insuppressing lung injury2011

    • Author(s)
      Furukawa M, Chuang VT, Ishima Y,Maruyama T, Otagiri M.
    • Journal Title

      J ControlRelease

      Volume: 154 Pages: 189-195

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cellular uptake mechanisms and responses to NO transferred from mono- and poly-S-nitrosated human serum albumin2011

    • Author(s)
      Yu Ishima., et al
    • Journal Title

      Free Radical Research

      Volume: 45 Issue: 10 Pages: 1196-1206

    • DOI

      10.3109/10715762.2011.606814

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human serum albumin-thioredoxin fusion protein with long blood retention property is effective in suppressing lung injury2011

    • Author(s)
      Furukawa M
    • Journal Title

      J Control Release

      Volume: 154 Issue: 2 Pages: 189-195

    • DOI

      10.1016/j.jconrel.2011.05.013

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Albumin fusion of thioredoxin--theproduction and evaluation of itsbiological activity for potentialtherapeutic applications2010

    • Author(s)
      kuta S,Chuang VT, Ishima Y, Maruyama T,Otagiri M.
    • Journal Title

      J ControlRelease

      Volume: 147 Pages: 17-23

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The critical role of nitric oxidesignaling, via proteinS-guanylation and nitrated cyclicGMP, in the antioxidant adaptiveresponse2010

    • Author(s)
      Fujii S, Okamoto T,Ahtesham AK, Ishima Y, Motohashi H,Yamamoto M, Akaike T.
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 23970-23984

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] One-step preparation ofS-nitrosated human serum albuminwith high biological activities2010

    • Author(s)
      Ishima Y, Hiroyama S, Kragh-HansenU, Maruyama T, Sawa T, Akaike T, KaiT, Otagiri M.
    • Journal Title

      Nitric Oxide

      Volume: 23 Pages: 121-127

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetically engineered mannosylatedhuman serum albumin as a versatilecarrier for liver-selectivetherapeutics2010

    • Author(s)
      Hirata K, Maruyama T,Watanabe H, Ishima Y, Hashida M,Otagiri M.
    • Journal Title

      J Control Release

      Volume: 145 Pages: 9-16

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hirata K, Maruyama T,Watanabe H, Ishima Y, Hashida M,Otagiri M.2010

    • Author(s)
      Katayama N, Nakajou K, Ishima Y, IkutaS, Yokoe JI, Yoshida F, Suenaga A,Maruyama T, Kai T, Otagiri M.
    • Journal Title

      Nitric Oxide

      Volume: 22 Pages: 259-265

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nitrosylated human serum albumin (SNO-HSA) induces apoptosis in tumor cells.2010

    • Author(s)
      Katayama N
    • Journal Title

      Nitric Oxide

      Volume: 22 Pages: 259-265

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response.2010

    • Author(s)
      Fujii S
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 23970-23984

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] One-step preparation of S-nitrosated human serum albumin with high biological activities.2010

    • Author(s)
      Ishima Y
    • Journal Title

      Nitric Oxide

      Volume: 23 Pages: 121-127

    • NAID

      120002971552

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Poly-S-nitrosated Human Serum Albumin inhibits the Expression of P-glycoprotein Transporter in Human Multidrug-resistant Tumor2013

    • Author(s)
      異島 優
    • Organizer
      AAPS Workshop on Drug Transporters in ADME
    • Place of Presentation
      Bethesda North Marriott Conference Center, Bethesda MD, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Poly-SNO-アルブミンによる抗癌剤耐性克服効果と機序解明2012

    • Author(s)
      異島優
    • Organizer
      日本薬学会
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒト血清アルブミンドメイン II によるビリルビン尿中排泄促進作用2012

    • Author(s)
      小田切 優樹 1,2,3)、蓑毛 藍 3)、異島 優 3)、 成底 徹 3)、 諏訪 喜昭 3)、渡邊 博志 3)、 森岡 弘志 3)、 丸山 徹3)
    • Organizer
      第28回日本 DDS 学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Related Report
      2012 Final Research Report
  • [Presentation] 高分子抗癌剤の腫瘍集積性を高める S -ニトロソ化アルブミンダイマーの EPR効果増強作用2012

    • Author(s)
      異島 優 1,2)、井上 亜希 1)、方 軍3)、前田 浩 4)、渡邊 博志 1,2)、小田切 優樹 1,3,4)、丸山 徹 1,2)
    • Organizer
      第28回日本 DDS 学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Related Report
      2012 Final Research Report
  • [Presentation] S-ニトロソ化に伴うα1-酸性糖タンパク質(AGP)の抗菌機能獲得と感染症治療への応用2012

    • Author(s)
      渡辺佳織 1, 異島 優 1, 2, 赤池孝章 3,澤 智裕 3, 黒田照夫 4, 小川和加野 4, 渡邊博志 1, 2, 甲斐俊哉 1, 5, 小田切優樹 1, 6, 7, 丸山徹 1, 2
    • Organizer
      第12回日本 NO 学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2012 Final Research Report
  • [Presentation] S-ニトロソ化アルブミンにより抗アポトーシス効果を付与した改良型臓器保存液の開発2012

    • Author(s)
      異島 優 1,2、 品川 拓也 1、 米重 梓二 1、 甲斐 俊哉 1、 赤池 孝章 3、 小田切 優樹 1,4,5、丸山 徹 1,2
    • Organizer
      第12回日本 NO学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2012 Final Research Report
  • [Presentation] S -ニトロソ化アルブミンダイマーはEPR 効果を増強する2012

    • Author(s)
      3、 前田 浩 4、 小田切 優樹 1,3,4、渡邊 博志 1,2、 丸山 徹 1
    • Organizer
      日本薬剤学会第27年会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2012 Final Research Report
  • [Presentation] ブレオマイシン誘発肺線維症に対するアルブミン-チオレドキシン融合体の有用性評価2012

    • Author(s)
      田中 遼大 1、 小玉 あずさ 1、 異島 優 1,2、 田中 健一郎 1、 水島徹 1、渡邊 博志 1,2、 小田切 優樹1,3,4、 丸山 徹 1,2
    • Organizer
      日本薬剤学会第27年会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規翻訳後修飾体である S -グアニル化アルブミンは抗菌効果を発揮する2012

    • Author(s)
      異島 優 1,2、 星野 瞳 1、 品川 拓也 1、 小田切 優樹 1,3,4、 渡邊 博志 1,2、丸山 徹 1,2
    • Organizer
      本薬剤学会第27年会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2012 Final Research Report
  • [Presentation] アルギニンペプチドを利用した細胞膜透過型アルブミンの設計と評価2012

    • Author(s)
      濱崎 慶輔 1、 渡邊 博志 1,2、 弥永 直樹 1、 國安 明彦 3、 異島 優1,2、 小田切 優樹 1,3,4、 丸山 徹 1,2
    • Organizer
      日本薬剤学会第27年会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2012 Final Research Report
  • [Presentation] ファージディスプレイ法を用いた尿毒症 物 質 3-carboxy-4-methyl-5-propyl-2-furan (CMPF)高親和性アルブミン変異体の設計2012

    • Author(s)
      西村 知晃 1、 蓑毛 藍 1、 異島 優1,2、 末永 綾香 1、 渡邊 博志 1,2、森岡 弘志 1、 小田切 優樹 1,3,4、 丸山 徹 1,2
    • Organizer
      日本薬剤学会第27年会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2012 Final Research Report
  • [Presentation] In vivo ファージディスプレイ法を用いた新規腎送達ペプチドの探索2012

    • Author(s)
      弥永 直樹 1、 渡邊 博志 1,2、 濱崎慶輔 1、 國安 明彦 3、 異島 優 1,2、小田切 優樹 1,3,4、 丸山 徹 1,2
    • Organizer
      日本薬剤学会第27年会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2012 Final Research Report
  • [Presentation] p-Cresyl sulfate causes renal tubularcell damage by inducing oxidativestress through the activation of NADPHoxidaseHiroshi2012

    • Author(s)
      Hiroshi Watanabe1,2, Daisuke Honda1,Yohei Miyamoto1, Tsuyoshi Noguchi1,Daisuke Kadowaki1,2, Yu Ishima1,2,Motoko Tanaka3, Hisae Tanaka4,Masafumi Fukagawa4, Masaki Otagiri1,5and Toru Maruyama1,2
    • Organizer
      49th ERA-EDTA Congress, Paris 2012
    • Place of Presentation
      Paris(France)
    • Related Report
      2012 Final Research Report
  • [Presentation] A uremic toxin,3-carboxy-4-methyl-5-propyl-2-furanpropionate accumulates inproximal tubular cells and inducescell damage through increasingoxidative stress2012

    • Author(s)
      Yohei Miyamoto1, Yasunori Iwao2,Katsumi Mera1, Hiroshi Watanabe1,3,Daisuke Kadowaki1,3, Yu Ishima1,Victor Tuan Giam Chuang4, KeizoSato5, Masaki Otagiri1.6 and ToruMaruyama1,3*
    • Organizer
      49th ERA-EDTACongress, Paris 2012
    • Place of Presentation
      Paris(France)
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規翻訳後修飾体であるS-グアニル化アルブミンは抗菌効果を発揮する2012

    • Author(s)
      異島 優
    • Organizer
      日本薬剤学会第27年会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Human serum albumin-thioredoxin fusion protein is effective in suppressing reactive oxygen species involved in lung injury2012

    • Author(s)
      異島 優
    • Organizer
      第33回内藤コンファレンス
    • Place of Presentation
      シャトレーゼ ガトーキングダム サッポロ
    • Related Report
      2012 Annual Research Report
  • [Presentation] S-ニトロソ化アルブミンにより抗アポトーシス効果を付与した改良型臓器保存液の開発2012

    • Author(s)
      異島 優
    • Organizer
      第12回日本NO学会学術集会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] 高分子抗癌剤の腫瘍集積性を高めるS-ニトロソ化アルブミンダイマーのEPR効果増強作用2012

    • Author(s)
      異島 優
    • Organizer
      第28回日本DDS学会
    • Place of Presentation
      札幌コンベンションセンター
    • Related Report
      2012 Annual Research Report
  • [Presentation] SNO-Albumin Dimerによる腫瘍組織への高分子抗癌剤デリバリー制御2012

    • Author(s)
      異島 優
    • Organizer
      第2回DDS製剤臨床応用FG合宿討論会
    • Place of Presentation
      箱根(帝京大学合宿所)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 高分子抗癌剤の腫瘍移行制御特性を有するSNO-Albumin Dimerの設計2012

    • Author(s)
      異島 優
    • Organizer
      創剤フォーラム
    • Place of Presentation
      徳島大学薬部長井記念ホール
    • Related Report
      2012 Annual Research Report
  • [Presentation] 一酸化窒素付加型アルブミンを用いた腫瘍組織への高分子抗癌剤デリバリー制御2012

    • Author(s)
      異島 優
    • Organizer
      崇城大学DDS研究所 第二回シンポジウム
    • Place of Presentation
      崇城大学薬学部
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ACUTE-PHASE PROTEIN ALPHA1-ACID GLYCOPROTEIN ACQUIRES ANTIBACTERIAL ACTIVITY THROUGH S-NITROSATION BY A NITRIC OXIDE-DEPENDENT MECHANISM2011

    • Author(s)
      Watanabe K
    • Organizer
      日本薬物動態学会
    • Place of Presentation
      広島国際会議場(広島県)
    • Year and Date
      2011-11-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 臓器移植保存液としてのs-ニトロン化アルブミンの有用性評価2011

    • Author(s)
      品川拓也
    • Organizer
      日本血液代替物学会
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2011-10-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Poly-SNO-アルブミンによる抗癌剤耐性克服効果2011

    • Author(s)
      異島優
    • Organizer
      日本DDS学会
    • Place of Presentation
      東京大学(東京都)
    • Year and Date
      2011-06-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mono-SNO-HSAとPoly- SNO-HSAによる細胞内NO輸送機構の解明2011

    • Author(s)
      異島優
    • Organizer
      日本NO学会
    • Place of Presentation
      昭和薬科大学(東京都)
    • Year and Date
      2011-05-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] 臓器障害に対する各種S-ニトロソ化ヒト血清アルブミンの保護効果2010

    • Author(s)
      米重梓二
    • Organizer
      第25回日本薬物動態学会年会
    • Place of Presentation
      大宮ソニックシティ(埼玉県)
    • Year and Date
      2010-10-08
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 腎臓集積性を示すペプチド、薬物2012

    • Inventor(s)
      渡邊博志
    • Industrial Property Rights Holder
      ニプロ株式会社
    • Industrial Property Number
      2012-097763
    • Filing Date
      2012-04-23
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 細胞膜透過性を有する製剤、細胞膜透過性組成物及び薬物輸送方法2012

    • Inventor(s)
      渡邊博志
    • Industrial Property Rights Holder
      ニプロ株式会社
    • Industrial Property Number
      2012-097762
    • Filing Date
      2012-04-23
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Patent(Industrial Property Rights)] 腎臓集積性を示すペプチド、薬物担体、製剤、医薬組成物2012

    • Inventor(s)
      渡邊博志
    • Industrial Property Rights Holder
      ニプロ株式会社
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-097763
    • Filing Date
      2012-04-23
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] S-ニトロソ化α1-酸性糖タンパク質を含有する抗菌剤2011

    • Inventor(s)
      異島 優
    • Industrial Property Rights Holder
      ニプロ株式会社
    • Filing Date
      2011-05-23
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 抗癌剤増感剤2011

    • Inventor(s)
      異島 優
    • Industrial Property Rights Holder
      ニプロ株式会社
    • Filing Date
      2011-03-29
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] S-ニトロン化α1-酸性糖タンパク質を含有する抗菌剤2011

    • Inventor(s)
      異島優
    • Industrial Property Rights Holder
      ニプロ株式会社
    • Filing Date
      2011-10-29
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗癌剤増感剤2011

    • Inventor(s)
      異島優
    • Industrial Property Rights Holder
      ニプロ株式会社
    • Filing Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 高リガンド親和性アルブミン変異体の製造方法2010

    • Inventor(s)
      異島 優
    • Industrial Property Rights Holder
      異島 優
    • Patent Publication Number
      2010-172277
    • Acquisition Date
      2010-08-12
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 高リガンド親和性アルブミン変異体の製造方法2010

    • Inventor(s)
      異島優
    • Industrial Property Rights Holder
      ニプロ株式会社
    • Patent Publication Number
      2010-172277
    • Acquisition Date
      2010-08-12
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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