| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
A patient's responsiveness to methotrexate(MTX) for treating rheumatoid arthritis(RA) has the individual differences. The present study examined genetic polymorphisms related to folate metabolism pathway and concentrations of MTX and its active form, MTX. polyglutamates(MTX. PGs), in red blood cells(RBCs) in RA patients. The patients with the G allele of the G80A polymorphism of the folate transporter gene RFC1 had less intracellular MTX uptake and therefore had poor efficacy ; a greater number of them were found to be biological preparations concomitant cases. The results of the present study suggest the possibility that the RFC1 G80A polymorphism and MTX. PGs levels in patients' RBCs may be a useful marker for predicting MTX efficacy in Japanese patients with RA.
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