Evaluation of a predict system of drug-induced depression by applying the circadian clock system
| Project/Area Number |
22790166
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 体内時計 / 薬物有害反応 / 転写活性 / うつ病 / 生体リズム / 視交叉上核 / 培養細胞 / 精神障害 |
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| Research Abstract |
It has been suggested that circadian clock dysfunction is involved in the onset of depression. This study revealed that interferon which frequently induces depression in clinical situation disturbed a rhythmicity of transcript activity of clock genes in cultured cells. In addition, it was revealed that circadian clock system regulates the expression rhythms of serotonin transporter which is related to depression, and of P-glycoprotein which controls pharmacokinetics of drugs.
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Report
(3 results)
Research Products
(7 results)
