| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
It has been suggested that circadian clock dysfunction is involved in the onset of depression. This study revealed that interferon which frequently induces depression in clinical situation disturbed a rhythmicity of transcript activity of clock genes in cultured cells. In addition, it was revealed that circadian clock system regulates the expression rhythms of serotonin transporter which is related to depression, and of P-glycoprotein which controls pharmacokinetics of drugs.
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