| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Research Abstract |
The genetic polymorphisms of Thiopurine S-methyl transferase (TPMT) and Inosine triphosphate pyrophosphatase (ITPA) were risk factor for increasing frequencies of adverse effects, which are leukopenia and liver toxicity, during maintenance therapy for acute lymphoblastic leukemia (ALL) in Japanese. The genetic mutation of multi-drug resistance protein 4 was increasing frequency of leukopenia during maintenance therapy for ALL.
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