Pharmacogenetics of 6-mercaptopurine maintenance therapy for acutelymphoblastic leukemia in Japanese
| Project/Area Number |
22790170
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | ファーマコジェネティクス / 6-メルカプトプリン / 小児白血病 / メルカプトプリン / 遺伝子多型 / 副作用 / ファーマコジェノミクス / 小児急性リンパ性白血病 / Thiopurine S-methyl transferase / Inosine triphosphate pyrophosphatase / Methylenetetrahydrofolate reductase / TPMT / ITPA / MTHFR / 薬物投与量 |
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| Research Abstract |
The genetic polymorphisms of Thiopurine S-methyl transferase (TPMT) and Inosine triphosphate pyrophosphatase (ITPA) were risk factor for increasing frequencies of adverse effects, which are leukopenia and liver toxicity, during maintenance therapy for acute lymphoblastic leukemia (ALL) in Japanese. The genetic mutation of multi-drug resistance protein 4 was increasing frequency of leukopenia during maintenance therapy for ALL.
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Report
(4 results)
Research Products
(16 results)
