Molecular mechanism of regulation of bile acids in fetoplacental unit and fetal toxicities by malfunction of the placenta

• Project/Area Number: 22790171
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Medical pharmacy
• Research Institution: Keio University
• Principal Investigator: NISHIMURA Tomohiro 慶應義塾大学, 薬学部, 助教 (40453518)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 胎児胎盤系 / 血液胎盤関門 / 胆汁酸 / トランスポーター / 胎児毒性 / 胆汁鬱滞 / 肝内胆汁うっ滞症

Research Abstract

This study has partly clarified that rat placental localization and the molecular function of a bile acid transporter, Slc10a3 which is a possible molecule regulating tissue and plasma concentration of bile acids and is expressed particularly in the placenta. It is essential that plasma concentration of bile acids is strictly controlled in the fetus for the normal fetal growth. The findings in the present study will be relevant to the relationship between malfunction of the placenta and deficiency of fetal growth.

Research Products

• [Journal Article] Mechanism of Nucleoside Uptake in Rat Placenta and Induction of Placental CNT2 in Experimental Diabetes (2012)
  • Author(s): Nishimura T, Chishu T, Tomi M, Nakamura R, Sato K, Kose N, Sai Y, Nakashima E
  • Journal Title: Drug Metabolism and Pharmacokinetics Volume: 27 Issue: 4 Pages: 439-446
  • DOI: 10.2133/dmpk.DMPK-11-RG-103
  • NAID: 130004463266
  • ISSN: 1347-4367, 1880-0920
  • Peer Reviewed
• [Journal Article] Mother-to-fetus transfer of antiviral drugs and the involvement of transporters at the placental barrier (2011)
  • Author(s): Tomi M, Nishimura T, Nakashima E.
  • Journal Title: J Pharm Sci Volume: 100 Issue: 9 Pages: 3708-3718
  • DOI: 10.1002/jps.22642
  • Peer Reviewed
• [Journal Article] Enhancement of zidovudine transfer to molt-4 cells, a human t-cell model, by dehydroepiandrosterone sulfate (2011)
  • Author(s): Nishimura T, Tanaka J, Tomi M, Seki Y, Kose N, Sai Y, Nakashima E.
  • Journal Title: J Pharm Sci Volume: 100 Issue: 9 Pages: 3959-3967
  • DOI: 10.1002/jps.22624
  • Peer Reviewed
• [Journal Article] Roles of TauT and system A in cytoprotection of rat syncytiotrophoblast cell line exposed to hypertonic stress (2010)
  • Author(s): Nishimura T, Sai Y, Fujii J, Muta M, Iizasa H, (他4名)
  • Journal Title: Placenta Volume: 31(11) Issue: 11 Pages: 1003-1009
  • DOI: 10.1016/j.placenta.2010.08.003
  • Peer Reviewed
• [Journal Article] Differential Expression of Ezrin and CLP36 in the Two Layers of Syncytiotrophoblast in Rats (2010)
  • Author(s): Higuchi K, Iizasa H, Sai Y, Horieya S, Lee K-E, Wada M, Deguchi M, Nishimura T, Wakayama T, Tamura A, Tsukita S, Kose N, Kang Y-S, Nakashima E.
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 33 Issue: 8 Pages: 1400-1406
  • DOI: 10.1248/bpb.33.1400
  • NAID: 130000300367
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed
• [Journal Article] Differential expression of ezrin and CLP36 in the two layers of syncytiotrophoblast in rats. (2010)
  • Author(s): Higuchi K, Iizasa H, Sai Y, Horieya S, Lee K-E, Wada M, Deguchi M, Nishimura T, Wakayama T, Tamura A, Tsukita S, Kose N, Kang Y-S, Nakashima E.
  • Journal Title: Biol Pharm Bull Volume: 33 Pages: 1400-1406
  • NAID: 130000300367
  • Peer Reviewed
• [Journal Article] Proton-coupled erythromycin antiport at rat blood-placenta barrier. (2010)
  • Author(s): Sai Y, Nishimura T, Ochi K, Tanaka N, Takagi A, Tomi M, Kose N, Kobayashi Y, Miyakoshi N, Kitagaki S, Mukai C, Nakashima E.
  • Journal Title: Drug Metab Dispos Volume: 38 Pages: 1576-1581
  • Peer Reviewed
• [Journal Article] Roles of TauT and system A in cytoprotection of rat syncytiotrophoblast cell line exposed to hypertonic stress. (2010)
  • Author(s): Nishimura T, Sai Y, Fujii J, Muta M, Iizasa H, Tomi M, Deureh M, Kose N, Nakashima E.
  • Journal Title: Placenta Volume: 31 Pages: 1003-1009
  • Peer Reviewed
• [Presentation] 胎盤発現トランスポーターSlc10a3の組織・細胞内局在解析 (2012)
  • Author(s): 山崎万郁、西村友宏、樋口慧、登美斉俊、中島恵美
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
• [Presentation] HMG-CoA還元酵素阻害薬のin vivoラット胎盤透過性の比較 (2010)
  • Author(s): 西村友宏、堀越美穂、登美斉俊、巨勢典子、中島恵美
  • Organizer: 日本薬剤学会第25年会
  • Place of Presentation: 徳島
• [Presentation] Improved transfer zidovudine by dehydroepiandrosterone sulfate in CD4(+) T lymphocyte, Molt-4 cells (2010)
  • Author(s): Nishimura T, Tomi M, Sai Y, Nakashima E
  • Organizer: ISSX 9th International Meeting
  • Place of Presentation: Istanbul, Turkey
• [Presentation] Improved transfer zidovudine by dehydroepiandrosterone sulfate in CD4(+) T lymphocyte, Molt-4 cells. (2010)
  • Author(s): Nishimura T, Tomi M, Sai Y, Nakashima E.
  • Organizer: ISSX 9th International Meeting
  • Place of Presentation: Istanbul, Turkey