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Evaluation of bioactive peptide kisspeptin as a biomarker

Research Project

Project/Area Number 22790172
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Medical pharmacy
Research InstitutionTokyo University of Pharmacy and Life Science

Principal Investigator

KATAGIRI Fumihiko  東京薬科大学, 薬学部, 助教 (60420642)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsペプチド / バイオマーカー / がん / 性腺機能低下症 / 周産期疾患 / キスペプチン / 妊娠高血圧症候群
Research Abstract

Kisspeptin is a bioactive peptide, which has been suggested to relate with cancers, hypogonadism, and perinatal disease. The author developed a sensitive enzyme immunoassay , which could measure blood kisspeptin concentrations, and tried to we identify diagnosable disease by plasma kisspeptin levels as a biomarker. Measuring and analysis of plasma/serum kisspeptin levels in healthy subjects and patients suggests that plasma kispeptin levels are expected to be a good biomarker for perinatal complication.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (14 results)

All 2012 2011 2010

All Journal Article (1 results) Presentation (10 results) Book (3 results)

  • [Journal Article] Usefulness of plasma kisspeptin levels as a biomarker in the diagnosis of perinatal complication2011

    • Author(s)
      Fumihiko Katagiri
    • Journal Title

      Peptide Science 2010

      Volume: (in press)

    • NAID

      10028237344

    • Related Report
      2010 Annual Research Report
  • [Presentation] Searching diagnosable disease using plasma kisspeptin levels as a biomarker2012

    • Author(s)
      F. Katagiri, M. Nomizu
    • Organizer
      The 32nd European Peptide Symposium
    • Place of Presentation
      Athens, Greece
    • Year and Date
      2012-09-02
    • Related Report
      2012 Final Research Report
  • [Presentation] Searching diagnosable disease using plasma kisspeptin levels as a biomaker2012

    • Author(s)
      F. Katagiri
    • Organizer
      The 32nd European Peptide Symposium
    • Place of Presentation
      Athens (Greece)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 血中キスペプチン濃度をバイオマーカーとして評価可能な疾患の探索2011

    • Author(s)
      片桐文彦、野水基義
    • Organizer
      第32回日本臨床薬理学会年会
    • Place of Presentation
      浜松
    • Year and Date
      2011-12-01
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] The worthiness of measurement of corculating kisspeptin levels in hypogonadism patients2011

    • Author(s)
      Fumihiko Katagiri
    • Organizer
      10th Congress of the European Association for Clinical Pharmacology
    • Place of Presentation
      Budapest (Hungary)
    • Year and Date
      2011-06-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] The worthiness of measurement of corculating kisspeptin levels in hypogonadism patients2011

    • Author(s)
      F. Katagiri, H. Mochiduki, N. Hirahara, K. Kawai, M. Kotani, M. Nomizu
    • Organizer
      10th Congress of the European Association for Clinical Pharmacology
    • Place of Presentation
      Budapest, Hungary
    • Year and Date
      2011-06-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Kisspeptin の低下を認めた持続性性腺機能低下症の1例2011

    • Author(s)
      望月晴子、川合弘太郎、平原直子、小谷仁人、片桐文彦、沖隆、中村浩淑
    • Organizer
      第20回臨床内分泌代謝 Update
    • Place of Presentation
      札幌
    • Year and Date
      2011-01-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Usefulness of plasma kisspeptin levels as abiomarker in the duagnosis of perinatal complication2010

    • Author(s)
      F . Katagiri, J. Yoshimatsu, Y.Furukawa, H. Narahara, M. Nomizu
    • Organizer
      5th International Peptide Symposium
    • Place of Presentation
      京都
    • Year and Date
      2010-12-04
    • Related Report
      2012 Final Research Report
  • [Presentation] 性腺機能低下症患者における血中キスペプチン濃度測定の意義2010

    • Author(s)
      片桐文彦、望月晴子、平原直子、川合弘太郎、小谷仁人、野水基義
    • Organizer
      第31回日本臨床薬理学会年会
    • Place of Presentation
      京都
    • Year and Date
      2010-12-01
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] 周産期疾患患者における血清中kisspeptin濃度測定の意義2010

    • Author(s)
      片桐文彦
    • Organizer
      第20回日本医療薬学会年会
    • Place of Presentation
      千葉
    • Year and Date
      2010-11-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] 周産期疾患患者における血清中kisspeptin 濃度測定の意義2010

    • Author(s)
      片桐文彦、古川雄一、楢原久司、野水基義
    • Organizer
      第20回日本医療薬学会年会
    • Place of Presentation
      千葉
    • Year and Date
      2010-11-13
    • Related Report
      2012 Final Research Report
  • [Book] The European Peptide Society , PEPTIDES 20122012

    • Author(s)
      F. Katagiri, et al
    • Total Pages
      2
    • Related Report
      2012 Final Research Report
  • [Book] The Japanese Peptide Society , Peptide Science 20102011

    • Author(s)
      F. Katagiri, et al
    • Total Pages
      1
    • Related Report
      2012 Final Research Report
  • [Book] Peptide Science 20102011

    • Author(s)
      Fumihiko Katagiri
    • Total Pages
      1
    • Publisher
      The Japanese Peptide Society
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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