The role of cellular prion protein in blood brain barrier

Research Project

Project/Area Number	22790178
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Medical pharmacy
Research Institution	Fukuoka University
Principal Investigator	WATANABE Takuya 福岡大学, 薬学部, 助教 (90509647)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	薬物動態 / 代謝学 / amyloid-β / 血液脳関門 / プリオン蛋白 / β-アミロイド
Research Abstract	This study aimed to address the role of cellular prion protein(PrPC) in amyloid-beta(Aβ) efflux via blood brain barrier. PrPC knockdown did not affect Aβ transport although other transporters(low density lipoprotein related protein 1 and P-glycoprotein) changed Aβ transport.

Report

(3 results)