Development of Immunomodulatory Cytokine mutants
Project/Area Number |
22790180
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Medical pharmacy
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Research Institution | 独立行政法人医薬基盤研究所 |
Principal Investigator |
ABE Yasuhiro 独立行政法人医薬基盤研究所, 創薬基盤研究部バイオ創薬プロジェクト, 研究員 (20509898)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 免疫誘導療法 / ファージ表面提示法 / サイトカイン / インターフェロン |
Research Abstract |
Type I interferons(IFNs) are pleiotropic cytokines that elicit antiviral and antiproliferative responses. In this study, we attempted to create a mutant IFN with higher anti-viral activity. At first, we constructed a phage library displaying IFN mutants. The phage library was performed to several rounds of panning to concentrate mutatnt IFN with high affinity to IFN receptor. As the results, some candidates exhibited higher affinity and anti-viral activity compare to wild type IFN.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Development of a novel antibody proteomics system using a phage antibody library for efficient screening of tumor-related biomarker proteins2011
Author(s)
Imai S, Nagano K, Yoshida Y, Okamura T, Yamashita T, Abe Y, Yoshikawa T, Yoshioka Y, Kamada H, Mukai Y, Nakagawa S, Tsutsumi Y, Tsunoda S
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Journal Title
Biomaterials
Volume: 32
Issue: 1
Pages: 162-169
DOI
Related Report
Peer Reviewed
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[Journal Article] Development of a novel antibody proteomics system using a phage antibody library for efficient screening of tumor-related biomarker proteins.2011
Author(s)
Imai S., Nagano K., Yoshida Y., Okamura T., Yamashita T., Abe Y., Yoshikawa T., Yoshioka Y., Kamada H., Mukai Y., Nakagawa S., Tsutsumi Y., Tsunoda S.
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Journal Title
Biomaterials
Volume: 32(1)
Pages: 162-169
Related Report
Peer Reviewed
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[Journal Article] The IL-1 family cytokines as mucosal vaccine adjuvant for the induction of protective immunity against influenza virus2010
Author(s)
Kayamuro H., Yoshioka Y., Abe Y., Arita S., Katayama K., Nomura T., Yoshikawa T., Kubota-Koketsu R., Ikuta K., Okamoto S., Mori Y., Kunisawa J., Kiyono H., Itoh N., Nagano K., Kamada H., Tsutsumi Y., Tsunoda S.
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Journal Title
J Virol.
Volume: 84(24)
Issue: 24
Pages: 12703-12
DOI
Related Report
Peer Reviewed
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[Journal Article] The IL-1 family cytokines as mucosal vaccine adjuvant for the induction of protective immunity against influenza virus.2010
Author(s)
Kayamuro H., Yoshioka Y., Abe Y., Arita S., Katayama K., Nomura T., Yoshikawa T., Kubota-Koketsu R., Ikuta K., Okamoto S., Mori Y., Kunisawa J., Kiyono H., Itoh N., Nagano K., Kamada H., Tsutsumi Y., Tsunoda S.
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Journal Title
J.Virol.
Volume: 84(24)
Pages: 12703-12
Related Report
Peer Reviewed
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[Presentation] Biological and structural characterization of human TNFR2-selective TNF mutants2011
Author(s)
Abe Y., Inoue M., Furuya T., Mukai Y., Nakamura T., Yamagata Y., Nabeshi H., Yoshikawa T., Yoshioka Y., Nagano K., Kamada H., Tsutsumi Y., Tsunoda S.
Organizer
9th Joint Meeting of ICS-ISICR(Cytokines2011)
Place of Presentation
Florence(Italy)
Related Report
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[Presentation] Selective inhibition of TNFR1 by mutant TNF with antagonistic activity is effective in the treatment of experimental autoimmune encephalomyelitis2011
Author(s)
Abe Y., Nomura T., Inoue M., Furuya T., Arita S., Nabeshi H., Yoshikawa T., Yoshioka Y., Nagano K., Kamada H., Tsutsumi Y., Tsunoda S.
Organizer
13th International TNF Conference
Place of Presentation
Awaji(Japan)
Related Report
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[Presentation] Biological and structural characterization of human TNFR2-selective TNF mutants2011
Author(s)
Abe Y, Inoue M, Furuya T, Mukai Y, Nakamura T, Yamagata Y, Nabeshi H, Yoshikawa T, Yoshioka Y, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S
Organizer
9th Joint Meeting of ICS-ISICR (Cytokines2011)
Place of Presentation
Florence (Italy)
Related Report
-
[Presentation] Selective inhibition of TNFR1 by mutant TNF with antagonistic activity is effective in the treatment of experimental autoimmune encephalomyelitis2011
Author(s)
Abe Y, Nomura T, Inoue M, Furuya T, Arita S, Nabeshi H, Yoshikawa T, Yoshioka Y, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S
Organizer
13th International TNF Conference
Place of Presentation
Awaji (Japan)
Related Report
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