Molecular mechanism of neuronal polarization mediated by downstream factors of SAD kinases.

• Project/Area Number: 22790184
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Niigata University
• Principal Investigator: KISHI Masashi 新潟大学, 医歯学系, 准教授 (60573938)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 神経細胞極性化 / 神経細胞極性 / SADキナーゼ / SAPS2 / asparaginase / 蛋白キナーゼ / 神経突起 / 軸索突起 / 樹状突起

Research Abstract

The SAD kinases play central roles for neuronal polarization. During this term, we tried bioinformatic identification of proteins with consensus sequences of SAD kinase-mediated phosphorylation. We identified two downstream molecules by this method. We also identified two direct binding partners by yeast two-hybrid screen.

Research Products

• [Journal Article] SAD kinases regulate neuronal polarization through Slingshot1 protein phosphatase (2012)
  • Author(s): Inutsuka A, Kishi M
  • Journal Title: Niigata Medical Journal Volume: 126(2)(in press)
  • NAID: 120006749227
  • Peer Reviewed
• [Journal Article] SADキナーゼによるSlingshot1フォスファターゼを介した神経細胞極性化の分子機構 (2012)
  • Author(s): 犬束歩岸将史
  • Journal Title: 新潟医学会雑誌 Volume: (in press)
  • NAID: 120006749227
  • Peer Reviewed
• [Presentation] Slingshot1 ; a SAD kinases' downstream molecule (2010)
  • Author(s): 岸将史
  • Organizer: 第661回新潟医学会特別講演
  • Place of Presentation: 有壬会館
  • Year and Date: 2010-10-16
• [Presentation] Protein Kinases Regulates Development of Neuronal Processes (2010)
  • Author(s): 岸将史
  • Organizer: 新潟脳神経研究会第289回例会特別講演
  • Place of Presentation: 新潟大学脳研究所
  • Year and Date: 2010-02-23
• [Remarks]
  • URL: http://www.niigata-u.ac.jp/tenure_track/researcher/kishi_masashi.html
• [Remarks]
  • URL: http://www.niigata-u.ac.jp/tenure_track/researcher/kishi_masashi.html
• [Remarks]
  • URL: http://www.niigata-u.ac.jp/tenure_track/researcher/kishi_masashi.html