| Project/Area Number |
22790187
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
General anatomy (including Histology/Embryology)
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
DING Guo 神戸大学, 医学研究科, グローバルCOE研究員 (00514697)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 発生学 / 形態形成学 / 血管 / リンパ管 / 吻合 / 分離 / 静脈角 |
|---|
| Research Abstract |
We investigated the formation of venous angles that the physiology connection site between blood vessels and lymphatic vessels. Also we analyzed the abnormal blood-lymph connection in Plcg2^<-/-> mice. Valves in venous angle were consist with blood endothelial cells and lymphatic endothelial cells(LECs) two layers cells. We detected the abnormal blood-lymph connection were randomly present in Plcg2^<-/-> and LEC extends filopodia to blood vessels at connection site. In addition, platelets inhibit proliferation and migration of LECs. Taken together, We proposed new molecular mechanisms : During lymphatic development, Platelets regulate the separation between blood and lymphatic vessel by inhibiting of proliferation and migration, inducing of retraction of lymphatic endothelial cells which encounter to blood vessels during lymphatic sprouting in the peripheral tissue.
|
