| Project/Area Number |
22790192
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Fujita Health University |
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Principal Investigator |
KOGO Hiroshi 藤田保健衛生大学, 総合医科学研究所, 助教 (20282387)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 減数分裂 / 不妊症 / 無精子症 / 不育症 / 不妊 / ノックアウトマウス / 性染色体 / 転写抑制 / リン酸化 / 無精子 / ヘテロクロマチン |
|---|
| Research Abstract |
The XY body is a specialized heterochromatic structure formed on the sex chromosomes during mammalian male meiosis. The failure of XY body formation leads to spermatocyte apoptosis, suggesting its crucial function in male gametogenesis. To date, however, the molecular basis of XY body formation has been largely unknown. In this study, we used gene targeting to generate mice lacking HORMAD2, a protein that localizes to the sex chromosome axes in mouse spermatocytes. Our results reveal that HORMAD2 is essential for the XY body formation via the recruitment of ATR activity.
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