Analysis of Dlg1 function in the development of the cardiac neural crest cells.
| Project/Area Number |
22790193
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Gunma University (2012)
Fujita Health University (2010-2011) |
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Principal Investigator |
KOGO Akiko 群馬大学, 大学院・医学系研究科, 助教 (20340242)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 器官形成 / Dlg1 / 心臓 / 神経堤細胞 / コルチ器 / 細胞極性 / マウス / ノックアウトマウス / 発生 / 腸管 / convergent extension / 内耳 / 有毛細胞 / Notch / 心室中隔欠損 / 心臓流出路 / トランスジェニックマウス |
|---|
| Research Abstract |
Dlg1 gene targeted mice exhibit congenital heart defects including outflow tract separation defect and ventricular septal defect. Distribution of cardiac neural crest cells did not exhibit retarded migration. On the other hand, elongation of organ of Corti, intestine, ureter and sternum was insufficient in these mice. As the convergent extension process was recently reported to be needed in the elongation of these tissues and in the outflow tract development, Dlg1 may be involved in the organogenesis through its role in the convergent extension.
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Report
(4 results)
Research Products
(23 results)
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Author(s)
Atsushi Yokoyama, Ryuji Nomura, Masafumi Kurosumi, Atsushi Shimomura, Takanori Onouchi, Akiko Iizuka-Kogo, Ron Smits, Naohisa Oda, Riccardo Fodde, Mitsuyasu Itoh, Takao Senda
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Journal Title
Medical Molecular Morphology
Volume: 44(4)
Pages: 207-212
Related Report
Peer Reviewed
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[Journal Article] Abnormal epithelial cell polarity andectopic epidermal growth factor receptor (EGFR) expression induced in Emx2 KO embryonic gonads2010
Author(s)
Masatomo Kusaka, Yuko Katoh-Fukui, Hidesato Ogawa, Kanako Miyabayashi, Takashi Baba, Noriyuki Sugiyama, Yukihiko Sugimoto, Yasushi Okuno, Ryuji Kodama, Akiko Iizuka-Kogo, Takao Senda, Shinichi Aizawa, Ken-ichirou Morohashi
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Journal Title
Endocrinology
Volume: 151(12)
Pages: 5893-904
Related Report
Peer Reviewed
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