Sweet Taste Receptor Expressed in Pancreatic・-Cells is Involved in Novel Insulin Secretion Pathway

• Project/Area Number: 22790200
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General physiology
• Research Institution: Gunma University
• Principal Investigator: NAKAGAWA Yuko 群馬大学, 生体調節研究所, 助教 (90422500)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: インスリン / シグナル伝達

Research Abstract

We analyzed the signal transmission mechanism in the β cell using the sharp system of measurement. As a result, we observed activation of Ca^<2+>, cAMP, diacylglycerol (DAG) and protein kinase C (PKC) being generated instantly in response to glucose stimulation . The response clarified that the new mechanism that was different from the metabolism-dependent reply that had been thought about conventionally in a glucose metabolism-independent object existed.

Research Products

• [Journal Article] Function of sweet taste receptor in pancreatic beta-cells (2011)
  • Author(s): Nakagawa, Y.
  • Journal Title: 生化学 Volume: 83(7) Pages: 647-651
  • Peer Reviewed
• [Journal Article] Interferon regulatory factor-2 regulates exocytosis mechanisms mediated by SNAREs in pancreatic acinar cells (2011)
  • Author(s): Mashima, H., Nakagawa, Y., Kojima, I., Ohnishi, H., 他3名, 4番目
  • Journal Title: Gastroenterology Volume: 141(3) Pages: 1102-1113
  • Peer Reviewed
• [Journal Article] Function of sweet taste receptor in pancreatic beta-cells (2011)
  • Author(s): 中川祐子
  • Journal Title: 生化学 Volume: 83 Pages: 647-651
  • Peer Reviewed
• [Journal Article] Interferon regulatory factor-2 regulates exocytosis mechanisms mediated by SNAREs in pancreatic acinar cells (2011)
  • Author(s): Mashima, H., Nakagawa Y., Kojima, I., Ohnishi, H., 他3名, 4番目
  • Journal Title: Gastroenterology Volume: 141 Pages: 1102-1113
  • Peer Reviewed
• [Journal Article] MCA1 and MCA2 that mediate Ca2+ uptake have distinct and over lapping roles in Arabidopsis. (2010)
  • Author(s): Yamanaka T., et al
  • Journal Title: Plant Physioligy Volume: 152 Pages: 1284-1296
  • Peer Reviewed
• [Presentation] 膵β細胞におけるグルコース作用:代謝に依存しないDAG産生経路の解明 (2011)
  • Organizer: 第54回日本糖尿病学会
  • Place of Presentation: 札幌
  • Year and Date: 2011-05-19
• [Presentation] 膵β細胞におけるグルコース作用:代謝に依存しないDAG産生経路の解明 (2011)
  • Author(s): 中川祐子
  • Organizer: 日本糖尿病学会
  • Place of Presentation: 札幌
  • Year and Date: 2011-05-19
• [Presentation] 膵β細胞におけるグルコース作用:代謝に依存しないシグナル伝達機構 (2010)
  • Organizer: 第53回日本糖尿病学会
  • Place of Presentation: 岡山
  • Year and Date: 2010-05-27
• [Presentation] 膵β細胞におけるグルコース作用:代謝に依存しないシグナル伝達経路の存在 (2010)
  • Author(s): 中川祐子
  • Organizer: 第7回 GPCR研究会
  • Place of Presentation: 岡崎市デジタルミュージアム
  • Year and Date: 2010-05-27
• [Presentation] 膵β細胞における甘味受容体の機能解析 (2010)
  • Author(s): 中川祐子
  • Organizer: 第7回 GPCR研究会
  • Place of Presentation: 日本未来科学館
  • Year and Date: 2010-05-07