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Architecture of top-down signals conveyed toward extrastriate cortex revealed by rabies virus in the macaque monkey.

Research Project

Project/Area Number 22790202
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General physiology
Research InstitutionThe University of Tokyo

Principal Investigator

SAWAMURA Hiromasa  東京大学, 医学部附属病院, 助教 (70444081)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords大脳視覚野 / 狂犬病ウイルス / マカクサル
Research Abstract

We investigated the architecture of multi-synaptic top-down pathways toward visual area4 (V4) of ventral stream and visual area 5 (MT/V5) of dorsal stream, employing retrograde trans-synaptic transport of rabies virus. In addition, multi-synaptic architecture from the medial temporal lobe to V4 was also investigated. We found that frontal inputs to MT/V5 and V4 mainly arise from area 46v. In addition, we found shot-cut pathway from the hippocampus proper to V4. These results indicate that multi-synaptic architecture may provide top-down information about object recognition accomplished throughoccipito-temporal and occipito-parietal pathways.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (18 results)

All 2012 2011 2010

All Journal Article (10 results) (of which Peer Reviewed: 6 results) Presentation (8 results)

  • [Journal Article] Segregated pathways carrying frontally derived top-down signals to visual areas MT and V4 in macaques.2012

    • Author(s)
      Ninomiya Taihei, Sawamura Hiromasa, Inoue Kenichi, Takada Masahiko.
    • Journal Title

      Journal of Neuroscience

      Volume: 32 Pages: 6851-6858

    • Related Report
      2012 Final Research Report
  • [Journal Article] Multisynaptic inputs from the medial temporal lobe to V4 in macaques.2012

    • Author(s)
      Ninomiya Taihei, Sawamura Hiromasa, Inoue Kenichi, Takada Masahiko.
    • Journal Title

      PLoS One

      Volume: 7

    • Related Report
      2012 Final Research Report
  • [Journal Article] Segregated pathways carrying frontally derived top-down signals to visual areas MT and V4 in macaques.2012

    • Author(s)
      Ninomiya Taihei, Sawamura Hiromasa, Inoue Ken-ichi, Takada Masahiko.
    • Journal Title

      J Neurosci.

      Volume: 32 Pages: 6851-6858

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multisynaptic Inputs from the Medial Temporal Lobe to V4 in Macaques2012

    • Author(s)
      Ninomiya T, Sawamura H, Inoue K, Takada M
    • Journal Title

      PLoS ONE

      Volume: 7 Issue: 12 Pages: e52115-e52115

    • DOI

      10.1371/journal.pone.0052115

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential architecture of multisynaptic geniculo-cortical pathways to V4 and MT.2011

    • Author(s)
      Ninomiya Taihei, Sawamura Hiromasa, Inoue Kenichi, Takada Masahiko.
    • Journal Title

      Cerebral Cortex

      Volume: 21 Pages: 2797-2808

    • Related Report
      2012 Final Research Report
  • [Journal Article] Differential architecture of multisynaptic geniculo-cortical pathways to V4 and MT2011

    • Author(s)
      Ninomiya T, Sawamura H, Inoue K, Takada M
    • Journal Title

      Cereb Cortex

      Volume: 21 Issue: 12 Pages: 2797

    • DOI

      10.1093/cercor/bhr078

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Default mode of brain function in monkeys2011

    • Author(s)
      Mantini D, Gerits A, Nelissen K, Durand JB, Joly O, Simone L, Sawamura H, Wardak C, Orban GA, Buckner RL, Vanduffel W
    • Journal Title

      Journal of Neuroscience

      Volume: 31 Issue: 36 Pages: 12954

    • DOI

      10.1523/jneurosci.2318-11.2011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Case of metastatic pulmonary carcinoma in optic disc diagnosed from results of biopsy performed during vitrectomy surgery2011

    • Author(s)
      Fukuda R, Tanabe T, Sawamura H, Kawata M, Tsuji H, Kaburaki T
    • Journal Title

      Graefe's Archive for Clinical and Experimental Ophthalmology

      Volume: 249 Issue: 12 Pages: 1883

    • DOI

      10.1007/s00417-011-1770-1

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficits in action selection based on numerical information after inactivation of the posterior parietal cortex in monkeys."2010

    • Author(s)
      Sawamura Hiromasa, Shima Keisetsu,Tanji Jun.
    • Journal Title

      J Neurophysiol.

      Volume: 104 Pages: 902-910

    • Related Report
      2012 Final Research Report
  • [Journal Article] Deficits in action selection based on numerical information after inactivation of the posterior parietal cortex in monkeys.2010

    • Author(s)
      Sawamura H, Shima K, Tanji J
    • Journal Title

      Journal of Neurophysiology

      Volume: 104 Pages: 902-910

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Multisynaptic inputs from the medial temporal lobe to V4 in macaques2012

    • Author(s)
      Sawamura Hiromasa, Ninomiya Taihei, Inoue Kenichi, Takada Masahiko.
    • Organizer
      Society For Neuroscience
    • Place of Presentation
      New Orleans,U.S.A.
    • Related Report
      2012 Final Research Report
  • [Presentation] Multisynaptic inputs from the medial temporal lobe to V4 in macaques2012

    • Author(s)
      Sawamura Hiromasa,Ninomiya Taihei, Inoue Ken-ichi, Takada Masahiko.
    • Organizer
      Society For Neuroscience
    • Place of Presentation
      New Orleans, United States of America
    • Related Report
      2012 Annual Research Report
  • [Presentation] 視覚の生理学的認知及び処理経路2011

    • Author(s)
      澤村裕正
    • Organizer
      第13回Japan Glaucoma Council
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-12-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Functional Organization and Circuitry of Extrastriate Cortex2011

    • Author(s)
      Ninomiya, Sawamura, et al
    • Organizer
      Society For Neuroscience 2011
    • Place of Presentation
      米国ワシントンDC
    • Year and Date
      2011-11-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] マカクザル前頭葉からMTおよびV4への多シナプス性入力様式.2011

    • Author(s)
      二宮太平、澤村裕正、井上謙一、高田昌彦
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜、日本
    • Year and Date
      2011-09-17
    • Related Report
      2012 Final Research Report
  • [Presentation] 視覚の生理学的認知及び処理経路2011

    • Author(s)
      澤村裕正
    • Organizer
      第115回日本眼科学会総会
    • Place of Presentation
      東京(シンポジスト)
    • Year and Date
      2011-05-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Functional organization and circuitry of extrastriate cortex2011

    • Author(s)
      Ninomiya Taihei, Sawamura Hiromasa, Inoue Kenichi, Takada Masahiko.
    • Organizer
      Society For Neuroscience
    • Place of Presentation
      Washington D.C., U.S.A.
    • Related Report
      2012 Final Research Report
  • [Presentation] サイトメガロ虹彩炎の再発回数2010

    • Author(s)
      澤村裕正
    • Organizer
      日本臨床眼科学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-11-11
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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