The functional analysis of epilepsy related gene TRPP3
Project/Area Number |
22790208
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
General physiology
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Research Institution | Kyoto University |
Principal Investigator |
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Project Period (FY) |
2010 – 2011
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Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | TRPP3 / TRPチャネル / 小児てんかん / TRP / てんかん / 電位依存性 / pH依存性 / Ca依存性 / Caチャネル |
Research Abstract |
Juvenile myoclonic epilepsy is the most frequently encountered and most common of the generalized epilepsy syndromes. In this research, mutations of the TRPP3 gene were detected in patients with Juvenile myoclonic epilepsy. Heterologous expression and functional analysis revealed abnormality in the 17 kinds of mutant channels.
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Report
(3 results)
Research Products
(40 results)
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[Journal Article] TRPA1 underlies a sensing mechanism for O_22011
Author(s)
Takahashi N, Kuwaki K, Kiyonaka S, Numata T, Kozai D, Mizuno Y, Yamamoto S, Naito S, Knevels E, Carmeliet P, Oga T, Kaneko S, Suga S, Nokami T, Yoshida J & Mori Y
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Journal Title
Nature Chem. Biol.
Volume: 7
Issue: 10
Pages: 701-711
DOI
Related Report
Peer Reviewed
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[Journal Article] TRPM1 is a component of the retinal ON bipolar cell transduction channel in themGluR6 cascade2010
Author(s)
Koike C, Obara T, Uriu Y, Numata T, Sanuki R, Miyata K, Koyasu T, Ueno S, Funabiki K, Tani A, Ueda H, Kondo M, Mori Y, Tachibana M & Furukawa T
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 107
Issue: 1
Pages: 332-337
DOI
Related Report
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[Journal Article] TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade.2010
Author(s)
Koike C, Obara T, Uriu Y, Numata T, Sanuki R, Miyata K, Koyasu T, Ueno S, Funabiki K, Tani A, Ueda H, Kondo M, Mori Y, Tachibana M, Furukawa T.
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Journal Title
Proc.Natl.Acad.Sci.U.S.A
Volume: 107
Pages: 332-337
Related Report
Peer Reviewed
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[Journal Article] Rim2α determins docking and priming states in insulin granule exocytosis.2010
Author(s)
Yasuda T, Shibasaki T, Minami K, Takahashi H, Mizoguchi A, Uriu Y, Numata T, Mori Y, Miyazaki J, Miki T, Seino S
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Journal Title
Cell Metabolism.
Volume: 4
Pages: 117-129
Related Report
Peer Reviewed
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