Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Research Abstract |
Voltage-gated proton channel VSOP regulates reactive oxygen species(ROS) in phagocytes. In this study, we found that VSOP deficient neutrophils release azurophilic granules excessively, which contain many kinds of degraded enzyme and myeloperoxidase(MPO) that catalyzes H2O2 to HOCl. The excessive release of azurophilic granules was dependent on the NADPH oxidase activity, which is enzyme to produce superoxide anion. These results suggest that VSOP negatively regulates the release of azurophilic granules to prevent tissue damage by degraded enzyme and HOCl.
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