The analysis of voltage-gated proton channel regulating NADPH oxidase activity
Project/Area Number |
22790212
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
General physiology
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Research Institution | Osaka University |
Principal Investigator |
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Project Period (FY) |
2010 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | プロトンチャネル / 活性酸素 / NADPHオキシダーゼ / 脱顆粒 / 電位依存性プロトンチャネル / 貪食細胞 |
Research Abstract |
Voltage-gated proton channel VSOP regulates reactive oxygen species(ROS) in phagocytes. In this study, we found that VSOP deficient neutrophils release azurophilic granules excessively, which contain many kinds of degraded enzyme and myeloperoxidase(MPO) that catalyzes H2O2 to HOCl. The excessive release of azurophilic granules was dependent on the NADPH oxidase activity, which is enzyme to produce superoxide anion. These results suggest that VSOP negatively regulates the release of azurophilic granules to prevent tissue damage by degraded enzyme and HOCl.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Novel and Conserved Protein Macoilin Is Required for Diverse Neuronal Functions in Caenorhabditis elegans2011
Author(s)
Miyara, A., Ohta, A., Okochi, Y., Tsukada, Y., Kuhara, A., Mori, I.
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Journal Title
PLoS Genetics
Volume: VOL.7
Issue: 5
Pages: 1-14
DOI
Related Report
Peer Reviewed
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