| Project/Area Number |
22790217
|
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
|
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| Research Institution | Kurume University (2011)
Jichi Medical University (2010) |
|---|
Principal Investigator |
|
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
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| Keywords | イオンチャネル / 心ペースメーカー細胞 / 持続性内向き電流 / NALCN / 背景Na^+電流 |
|---|
| Research Abstract |
In this study, we tried to elucidate the molecular mechanisms underlying sustained inward current(Ist), a pacemaker cell specific current in sinoatrial node. RT-PCR analysis revealed that the recently identified new Cav1.3(1b) isoform was specifically expressed in the sinoatrial node, but not Cav1.3(1a). Heterologous expression of Cav1.3(1b) in Xenopus oocytes induced Ca^<2+> currents, but failed to induce Na^+currents similar to Ist.
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